Structure of PDB 1ofh Chain G Binding Site BS01

Receptor Information

>1ofh Chain G (length=173) Species: 71421 (Haemophilus influenzae Rd KW20)

TTIVSVRRNGQVVVGGDGQVSLGNTVMKGNARKVRRLYNGKVLAGFAGGT
ADAFTLFELFERKLEMHQGHLLKSAVELAKDWRTDRALRKLEAMLIVADE
KESLIITGIGDVVQPEEDQILAIGSGGNYALSAARALVENTELSAHEIVE
KSLRIAGDICVFTNTNFTIEELP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1ofh Chain G Residue 454

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1ofh Structure and Reactivity of an Asymmetric Complex between Hslv and I-Domain Deleted Hslu, a Prokaryotic Homolog of the Eukaryotic Proteasome
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): G157 C160 T163
• Binding residue (residue number reindexed from 1): G157 C160 T163
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): T1 K33 G45 S125
• Catalytic site (residue number reindexed from 1): T1 K33 G45 S125
• Enzyme Commision number: 3.4.25.2: HslU--HslV peptidase.

Gene Ontology

Molecular Function

• GO:0004298 threonine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis
• GO:0030163 protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005839 proteasome core complex
• GO:0009376 HslUV protease complex

External links

• PDB: RCSB:1ofh, PDBe:1ofh, PDBj:1ofh
• PDBsum: 1ofh
• PubMed: 12823960
• UniProt: P43772|HSLV_HAEIN ATP-dependent protease subunit HslV (Gene Name=hslV)