Structure of PDB 1jd2 Chain G Binding Site BS01

Receptor Information

>1jd2 Chain G (length=243) Species: 4932 (Saccharomyces cerevisiae)

AGYDRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKV
PDKLLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYG
YDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDP
AGYYVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITH
MIDALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 1jd2 Chain G Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1jd2 Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): T13 Y123 R126 M129
• Binding residue (residue number reindexed from 1): T8 Y119 R122 M125
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.99.46: Transferred entry: 3.4.25.1.

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding

Biological Process

• GO:0006511 ubiquitin-dependent protein catabolic process
• GO:0010499 proteasomal ubiquitin-independent protein catabolic process
• GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

Cellular Component

• GO:0000502 proteasome complex
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005839 proteasome core complex
• GO:0019773 proteasome core complex, alpha-subunit complex

External links

• PDB: RCSB:1jd2, PDBe:1jd2, PDBj:1jd2
• PDBsum: 1jd2
• PubMed: 11493007
• UniProt: P21243|PSA1_YEAST Proteasome subunit alpha type-1 (Gene Name=SCL1)