Structure of PDB 7zx1 Chain FFF Binding Site BS01

Receptor Information
>7zx1 Chain FFF (length=634) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRDDGFPIKGCDDTL
VVGLAVCWGGRDAYYFSLQKEPPSLDPSLTLKDRMWYLQSCLRKESDKEC
SVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVT
SFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQL
NSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKL
DAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPFSTSKDVLNKLKALH
PLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGR
ITFTEPNIQNVPRDFEIKMGGMPFSISMRHAFVPFPGGSILAADYSQLEL
RILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQIC
YGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKR
DGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATV
NIQKQLETFHSTFKSHGHRECPIRGGFFILQLHDELLYEVAEEDVVQVAQ
IVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV
Ligand information
Receptor-Ligand Complex Structure
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PDB7zx1 Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta.
Resolution2.829 Å
Binding residue
(original residue number in PDB)		T2237 A2238 T2239 T2243 T2245 N2248 N2251 Y2391 M2393 G2394 S2397 R2448 Y2459 H2463 R2466 N2470 Q2474
Binding residue
(residue number reindexed from 1)		T346 A347 T348 T352 T354 N357 N360 Y455 M457 G458 S461 R512 Y523 H527 R530 N534 Q538
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7zx1, PDBe:7zx1, PDBj:7zx1
PDBsum7zx1
PubMed36200480
UniProtO75417|DPOLQ_HUMAN DNA polymerase theta (Gene Name=POLQ)

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