Structure of PDB 6sgb Chain FF Binding Site BS01

Receptor Information
>6sgb Chain FF (length=408) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKRIVVPHRWSEMNRVEHPPLMMKQLFQGVCGGLRWLETKSLAQYLAVRA
IEEGYPSTPGVRSLQVTKQKRLVSYDVLDCTLGSGYHAGAVLENGGPYTR
VVALDCDHDAMHAARDLVEEFGGDRFRFYCCKMSEAKAMFGERSFDAIMI
DGGVSDTQLEDPERGFLLDDEGGHRLDMRFGPQMGVGALEYLNTVSQHTL
VSSLLAYGLLEYGQAMKMSRAITRRKPFVDSREVLTCIEQAGDELPEGGW
RSQGSRRKSPMSWKFLTSLRCIINNEMYELRQGIENALLMLRDDGRLVVF
SRLPWEERLVRGTVDDHPHALLSYVEDISIDDVQIYGFTRHAKMWVITRA
ASSAYALKNTTTLTEEKFRESSVRWLTGMYAGQTHGFPANNFTFENFERK
EWVTLRRN
Ligand information
>6sgb Chain Cn (length=27) Species: 5702 (Trypanosoma brucei brucei) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RWAAKFYGQVTFGPRNYPYPSSRWLAR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6sgb Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Q250 H251 M269
Binding residue
(residue number reindexed from 1)		Q197 H198 M216
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0070475 rRNA base methylation
Cellular Component
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6sgb, PDBe:6sgb, PDBj:6sgb
PDBsum6sgb
PubMed31515389
UniProtQ57W60

[Back to BioLiP]