Structure of PDB 8ipa Chain FA Binding Site BS01

Receptor Information
>8ipa Chain FA (length=185) Species: 4565 (Triticum aestivum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTILASETMEIPEEVTVKVSAKMISVTGPRGTLTRNFKHLNLDFQLQEGG
RKLKVDAWFGTRKTMAAIRTAISHVQNLITGVTKGFRYKMRFVYAHFPIN
ASITAANRGIEIRNFLGEKKVRKVDMLDGVTILRSEKVKDEIVLDGNDIE
LVSRSAALINQKCHVKNKDIRKFLDGIYVSDKGAI
Ligand information
>8ipa Chain RB (length=3147) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgcgaccccaggucaggcgggacuaccgcugaguuuaagcauauaaaua
agcggaggagaagaaacuuacaaggauuccccuaguaacggcgagcgaac
cgggagcagcccagcuugagaaucgggcggcugugccguccgaauuguag
ucuggagaggcguccucagcgacggaccgggcccaaguccccuggaaagg
ggcgccugggagggugagagccccguccggcccggacccugucgccccac
gaggcgccgucaacgagucggguuguuugggaaugcagcccaaaucgggc
gguagacuccguccaaggcuaaauacaggcgagagaccgauagcgaacaa
guaccgcgagggaaagaugaaaaggacuuugaaaagagagucaaagagug
cuugaaauugccgggagggaagcggaugggggccggcgaugcgccccggc
gcucggggcguggacuguugucggccgcgccggcggccaaagcccggggg
cuccgcgcccccggcagccgucgucggcacggccgguacccgcgcgccga
aaggcgugccccucggggcacugcgcugcaacgcccugcgggcucuccau
ccgacccgucuugaaacacggaccaaggagucugacaugcgugcgagucg
acggguucugaaaccugggaugcgcaaggaagcugacgagcgggaggccc
ucacgggccgcaccgcuggccgacccugaucuucugugaaggguucgagu
uggagcacgccugucgggacccgaaagauggugaacuaugccugagcggg
gcgaagccagaggaaacucugguggaggcucgaagcgauacugacgugca
aaucguucgucugacuuggguauaggggcgaaagacuaaucgaaccaucu
aguagcugguucccuccgaaguuucccucaggauagcuggagcccauuac
gaguucuaucagguaaagccaaugauuagaggcauuggggacgcaacguc
cucgaccuauucucaaacuuuaaauagguaggauggcgcggcugcuucgg
ugagccgugccauggaaucgggugcuccaagugggccauuuuugguaagc
agaacuggcgaugcgggaugaaccggaagccggguuacggugcccaacug
cgcgcuaaccuagaacccacaaaggguguuggucgauuaagacagcagga
cgguggucauggaagucgaaauccgcuaaggaguguguaacaacucaccu
gccgaaucaacuagccccgaaaauggauggcgcugaagcgcgcgacccac
acccggccaucugggcgagugccaugccccgaugaguaggagggcgcggc
ggccgaugcaaaacccggggcgcgagcccgggcggagcggccgucggugc
agaucuuggugguaguagcaaauauucaaaugagaacuuugaaggccgaa
gaggagaaagguuccaugugaacggcacuugcacauggguaagccgaucc
uaagggaagggguaaccccggcagauagcgcgaucacgcgcauccccgaa
agggaaucggguuaagauuucccgagccgggauguggcgguugacggcga
cguuaggaaguccggagacgccggcgggggccucgggaagaguuaucuuu
ucugcuuaacggccugccaacccuggaaacgguucagccggagguagggu
ccaguggccggaagagcacacgucgcgcgguguccggugcgcccccggcg
gcccaugaaaauccggaggaccgaguaccguucacgcccggucguacuca
uaaccgcaucaggucuccaaggugaacagccucuggccaauggaacaaug
uaggcaagggaagucggcaaaacggauccguaacuucgggaaaaggauug
gcucugaggacugacagucgacucagaacugguacggacaaggggaaucc
gacuguuuaauuaaaacaaagcauugcgaugguccucgcggaugcugacg
caaugugauuucugcccagugcucugaaugucaaagugaagaaauucaac
caagcgcggguaaacggcgggaguaacuaugacucucuuaagguagccaa
augccucgucaucuaauuagugacgcgcaugaaugaauuaacgagauucc
cacugucccugucuacuauccagcgaaaccacagccaagggaacgggcuu
ggcggaaucagcggggaaagaagacccuguugagcuugacucuaguccga
cuuugugaaaugaauuuuacuuauuccgugggucggaagcggggcaugcc
ccuccuuuuggcuccaaggcccggucuuaccgggccgauccgggcggaag
acauugucagguggggaguuuggcuggggcggccaaucuguuaaaagaua
acgcagguguccuaagaugagcucaacgagaacagaaaucucguguggaa
caaaaggguaaaagcucguuugauucugauuuccaguacgaauacgaacc
gugaaagcguggccuaucgauccuuuagaucuucggaguuugaagcuaga
ggugucagaaaaguuaccacagggauuacuggcuuguggcagccaagcgu
ucauagcgacguugcuuuuugauccuucgaugucggcucuuccuaucauu
gcgaagcagaauucaccaaguguuggauuguucacccaccaauagggaac
gugagcuggguuuagaccgucgugagacagguuaguuuuacccuacugau
gacagugucgcgauaguaauucaaccuaguacgagaggaaccguugauuc
acacaauuggucaucgcgcuugguugaaaagccaguggcgcgaagcuacc
gugugccggauuaugacugaacgccucuaagucagaauccaagcuagcau
gcgacgccugcgcccgccgcccgccccgacccacguuaggggcgcuugcg
cccccaagggcccgugccauuggcuaagccgguccggccgaagugccgcg
gucggccgccucgaagcucccuucccaacgggcggugggcugaauccuuu
gcagacgacuuaaauacgcgacggggcauuguaaguggcagaguggccuu
gcugccacgauccacugagauccaguccccgggucgcacggauucgu
..........................<<<<<.....<......>......
>>>>>...........<<....>>..<<<<<.......<.....>.....
.>>>>>..[[[....<......<<<<<<<<<...>>>>>>>>>......>
......<<<<<<.<<<<.<<<<<<<.<<<<<<<.....<<<<......>>
>>.((......<<<.....))>>>....>>>>>>>...>>>>>>>.....
>>>>>>>>.>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<......<<<<<<<<<.
..>>>>>>>>>.<..<<<<<<<<<<<<.<<<<<<<<<......<<<<<<<
.......>>>>>>>.....>>>>>>>>>.>>>>>>>.....<<<<<<<..
..>>>.<<<<<<..>>>>>>..>>>>..>>>>>..>....>>>.>>>>>>
>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<..
..<<<<<....>>>>>.....>>...<<....>>....<<<<<..<<<<<
....>>>>>...>>>>><<<<<<<<.....<....>.....>>.>>>.>>
>...>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<....<
<<.<<<<<<<.....<<<....<<<..<.<<<.....<<<<.......>>
>>...>>>.>..>>>..>.>>.....>>>>>...<<<<<<<<<.<.....
.>>>>>>>>>>....>>>>>>>.>>>>>>.>>..<<<<.<<<<<.....>
>>>>.>>>>....<<<......>>>...<<<<<<<...<<<(((.....<
<<<<<......<<..........<<<.<<<<<<.<<<.......<<<...
<<.....<.........>.....>>........................>
>>...>>>.>>>>>>>>>..........))).>>...>>>>>>.>>>...
>>>>>>><<<<.<<<<.........>>>>.>>>>....>>>>>>..<<<<
<<<<<........<<<.<<<<....>>>>>>>.....>>>>>>>>>....
....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<...
..<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<
...<<<...<<<....>>>.........<<<<....>>>>....>>>...
.>>...<<<<<.........>>>>>))<<<<.<<<<<<<<...<<<....
>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<.<<<<.......>
>>>.><...<<<<<.....<<<<<<....<<<<...>>>>....>>>>>>
.....>>>>>....><<<<..........>>>>>>>>...>>>>>>>.>>
>>.........>>>>>>..........>>>>.>>>>>>>>>>>>..>>..
...<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<.....<
<<<<<<.<<.........<.....<<<<<.....<..>......>>>>><
<.<<<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<
<..<<<.........>>>..<<<<<<<....<<<<....>>>>......>
>>>>>>...<<<.<<<..<<<<<<.....<<.....<<<<....>>>>..
...>>..>>>>..>>>>><<<<<<.......>>>>>>........<....
.......<<<<<.......>>>>>.....>....>>>....>>.>>>>>>
>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>>>
>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<<.<<<.<<
<...<<<<<<<..>>>>>>>...<<<<<.....<<<<...<<<<....>>
>>...............<<<<<<.......>>>>>>..>>>>..>>>>>.
.....>>>.>>>..>>>>>...<<<.....>>>..<<<<<<.........
..>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<
<...(((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<
<<....>>>.>>))).......((((((..((((.>>>>>>)))))))))
)..........]]]]..}}]]]].......<<.<.<.<<<<<<...<<..
.....>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<<<.
<.<<<......>>>.>...>>>.<<<.........>>>.....>>>>>..
>...>>>.>>....<<<<<<<....>>>.>>>>....}}..}}}.]]]]]
....<<<<<<<..<<<<.<.<<<<<.................>>>>>.><
<<<<...<<<<....<<<<<<<<<......>>>>..>>>>>...>>>>..
>>>>>..<<<...<<<<<...........>>>>>...>>>..>>>>....
>>>>>>>....<<<<<<<<<<<<......<<.......<<<<<<<..>>>
>>>>....>>...........<<<...<<<<<<<<<<<......>>>>.>
>>>>>>.>>>..................>>>>>>>>>>>>.<<<<<<<..
...........>.....<<<<<<<<<.<<<....<<<<.<..<<<<<...
...>>>>>..>>>>>...>>>....>>>>...>>>>>..>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ipa Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
Resolution3.4 Å
Binding residue
(original residue number in PDB)
K2 A22 H40 N42 L43 W59 R63 K64 A67 T71 S74 H75 N78 H97 F98 E119 K120 K121 S154 R155 L159 Q162 K169 D170 R172 K173 F174
Binding residue
(residue number reindexed from 1)
K1 A21 H39 N41 L42 W58 R62 K63 A66 T70 S73 H74 N77 H96 F97 E118 K119 K120 S153 R154 L158 Q161 K168 D169 R171 K172 F173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8ipa, PDBe:8ipa, PDBj:8ipa
PDBsum8ipa
PubMed38267667
UniProtW5I5G5

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