Structure of PDB 6qnr Chain F8 Binding Site BS01

Receptor Information

>6qnr Chain F8 (length=95) Species: 300852 (Thermus thermophilus HB8)

MKTAYDVILAPVLSEKAYAGFAEGKYTFWVHPKATKTEIKNAVETAFKVK
VVKVNTLHVRGKKKRLGRYLGKRPDRKKAIVQVAPGQKIEALEGL

Ligand information

>6qnr Chain 1H (length=2890)

ggucaagaugguaagggcccacgguggaugccucggcacccgagccgaug
aaggacguggcuaccugcgauaagccagggggagccgguagcgggcgugg
aucccuggauguccgaaugggggaacccggccggcgggaacgccggucac
cgcgcuuuuugcgcggggggaaccuggggaacugaaacaucucaguaccc
agaggagaggaaagagaaaucgacucccugaguagcggcgagcgaaaggg
gaccagccuaaaccguccggcuuguccgggcggggucguggggcccucgg
accgaauccccagccuagccgaagcuguugggaagcagcgccagagaggg
ugaaagccccguaggcgaaagguggggggauaggugaggguacccgagua
ccccgugguucguggagccaugggggaaucugggcggaccaccgccuaag
gcuaaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggu
gaaaagaaccccgggaggggagugaaauagagccugaaaccgugggcuua
caagcagucacggccccgcaagggguuguggcgugccuauugaagcauga
gccggcgacucacggucgugggcgagcuuaagccguugaggcggaggcgu
agggaaaccgaguccgaacagggcgcaaacggccgaaaaguccgcggccg
uggacccgaaaccgggcgagcuagcccuggccagggugaagcugggguga
gacccaguggaggcccgaaccggugggggaugcaaaccccucggaugagc
uggggcuaggagugaaaagcuaaccgagcccggagauagcugguucuccc
cgaaaugacuuuagggucagccucaggcgcugacuggggccuguagagca
cugauagggcuagggggcccaccagccuaccaaacccugucaaacuccga
agggucccagguggagccugggagugagggcgcgagcgauaacguccgcg
uccgagcgcgggaacaaccgagaccgccagcuaaggcccccaagucuggg
cuaagugguaaaggauguggcgccgcgaagacagccaggauguuggagca
gccaucauuuaaagagugcguuagcucacuggucgaguggcgccgcgccg
aaaaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaug
accccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcg
agggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaa
agagggugagaaucccucucgccguaagcccaaggguuccuacgcaaugg
ucgucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagc
cgaagggcagccgguuaauauuccggcccuucccgcaggugcgauggggg
gacgcucuaggcuagggggaccggagccauggacgagcccggccagaagc
gcagggugggagguaggcaaauccgccucccaacaagcucugcguggugg
ggaagcccguacgggugacaaccccccgaagccagggagccaagaaaagc
cucuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggc
gggugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucug
caaguuggccccguaacuucgggagaaggggugcucccuggggugaugag
ccccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacac
agcucucugcgaacucguaagaggagguauagggagcgacgcuugcccgg
ugccggaaggucaaggggaggggugcaagccccgaaccgaagccccggug
aacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgg
guaaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggc
gagggacccggugaaauugaacuggccgugaagaugcggccuacccgugg
caggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuu
ggucgcgccugcguaggauaggugggagccugugaacccccgccuccggg
ugggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaa
cccucggauggggggacagcgcuuggcgggcaguuugacuggggcggucg
ccuccuaaaagguaacggaggcgcccaaagguccccucaggcgggacgga
aauccgccggagagcgcaaggguagaagggggccugacugcgaggccugc
aagccgagcaggggcgaaagccgggccuagugaaccgguggucccgugug
gaagggccaucgaucaacggauaaaaguuaccccggggauaacaggcuga
ucucccccgagcguccacagcggcggggagguuuggcaccucgaugucgg
cucgucgcauccuggggcugaagaaggucccaaggguugggcuguucgcc
cauuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggu
cucuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacg
agaggaccggaagggacgcaccucugguuucccagcugucccuccagggg
cauaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaa
gcgggaagcccgccccaagaugaggccucccacggcgucaagccgguaag
gacccgggaagaccacccgguggaugggccggggguguaagcgccgcgag
gcguugagccgaccggucccaaucguccgaggucuugacc

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..<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>....
.>>>>>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<
<<<<<.....>>>>>>.>>...<<<<<<.....<<....>>......>>>
>>.>.........<<....>>...<<<<<.....<<.....>>....>>>
>>...(((....<<<<<<<<.....>>>>>>>>......<<<<<<<<<..
<<<...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<
.....))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....
<<<<<<<<<.......>>>>>>>>>......<<<<<..<<<<>>>>>..)
))......]].>>>>>>.]]...............<<....>>....]].
........<<<<....>>>>..................>>>>>>>>>>>.
......<<<<<<<<<<<....>>>>>>>>>>>...<............>.
<<<<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>..
.<<....>>..<<<<.....>>>>.....<<..>>....>>>>>>>>>>>
>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<....
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.>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>
>>>.....<<<......>>>...<<<<.<<<...<<<(((.....<<<<<
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.>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<.<<<...
.>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....
<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.
....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>
>...>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.
...<<<<<.<<<..<<<<<.<<<<.<<..((((...>>>>>><<<...<<
<<<<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>>
<...<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>
>>>...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>
.<<<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<........
.<.....<<<<<...............>>>>><<<<<<<<<<<<.....>
>>>>>>>>>>>............<<<<<<<<<..<<<.........>>>.
.<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<
<<<<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>.
.>>>>><<<<<<.......>>>>>>........<...........<<<<<
<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.(((.........<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<<<
<<<<<<<<<...........<<.<<..<<<.......<<<<<<<....>>
>>>>>....>>>............>>.>>..>>>>>>>>>>>>>>>>...
<<<<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<....
..>>>..>>>>.<<<....>>>.>>))).......<<<<<<.(((..>>>
>..)))>>>>>>.............>>>>..]]>>>>.......<<<<..
.<<<<<<<..<<.......>>>..>>>>>>....>>>.>.......<<<<
<.<<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>
>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...
.....)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......
........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>
>>...>>>>>...>>>>.>>>>>...<<<....<<<<<...........>
>>>>....>>>.>>>>.......>>>>>>>..<<<<.....>>>>....<
<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>
>>>>...>>>..>>>>>.>>>...>>>>....>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qnr Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): K2 S14 K16 K25 H31 T35 K36 T37 E38 K40 N41 E44 K50 K53 N55 T56 L57 H58 R60 K62 K64 L66 Y69 L70 G71 K72 R73 D75 I80
• Binding residue (residue number reindexed from 1): K2 S14 K16 K25 H31 T35 K36 T37 E38 K40 N41 E44 K50 K53 N55 T56 L57 H58 R60 K62 K64 L66 Y69 L70 G71 K72 R73 D75 I80

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qnr, PDBe:6qnr, PDBj:6qnr
• PDBsum: 6qnr
• PubMed: 31175275
• UniProt: Q5SHP0|RL23_THET8 Large ribosomal subunit protein uL23 (Gene Name=rplW)