Structure of PDB 7r81 Chain F2 Binding Site BS01

Receptor Information
>7r81 Chain F2 (length=256) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRGPKKHQKRLSAPSHWLLDKLSGVYAPRPSAGPHKLRECMPLIVFVRNR
LKYALNYRETKAIMMQRLIKVDGKVRTDITYPAGFMDVITIEKTGENFRL
IYDTKGRFTVHRIQDEEAKYKLGKVKRVQLGKGGIPFLVTHDARTIRYPD
PLIKVNDTVKINLETGKIEDFVKFDTGAIAMVTGGRNMGRVGVITHRERH
DGGFNIIHVKDALDNTFATRESNVFVIGSEKPWISLPKGKGVKLSIAEER
DRRRAN
Ligand information
>7r81 Chain A2 (length=1769) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauucugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguuuaagcaauuaaaccgcgaaacugcgaauggcucau
uaaaucaguuauaguuuauuugauaguaccuuacuacauggauaaccgug
guaauucuagagcuaauacaugcuaaaaaccccgacuucagggguguauu
uauuagauuaaaaaccaaugcccuucggggcuaacuggugauucauaaua
acuucucgaaucgcauggccuugcgcuggcgaugguucauucaaauuucu
gcccuaucaacuuucgacggcugggucuuggccagccauggugacaacgg
guaacggaggguuagggcucgaccccggagaaggagccugagaaacggcu
acuacauccaaggaaggcagcaggcgcgcaaauuacccaaucccgacacg
gggagguagugacaauaaauacugauacagggcucuuuugggucuuguaa
uuggaaugaguacaauuuaaaucccuuaacgaggaacaauuggagggcaa
gucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaa
guuguugagguuaaaaagcucguaguugaaccuugggcucggcccgucgg
uccugggucgggccuuuccuggagaaccgcaugcccuucacugggugugu
cggggaaccaggacuuuuaccgugaacaaaucagaucgcucaaagaaggc
cuaugcucgaauguacuagcauggaauaauagaauaggacgugugguucu
auuuuguugguuucuaggaccgccguaaugauuaauagggacagucgggg
gcaucaguauucaauugucagaggugaaauucuuggauuuauugaagacu
aacuacugcgaaagcauuugccaaggauguuuucauuaaucaggaacgaa
aguuaggggaucgaagacgaucagauaccgucguagucuuaaccauaaac
uaugccgauuagggaucggacgguguuauuuuuugacccguucggcaccu
uacgauaaaucaaaauguuugggcuccugggggaguauggucgcaaggcu
gaaacuuaaagaaauugacggaagggcaccaccagggguggagccugcgg
cuuaauuugacucaacacggggaaacucaccagguccagacacgaugagg
auugacagauugagagcucuuucuugauuucgugggugguggugcauggc
cguucuuaguugguggagugauuugucugcuuaauugcgauaacgaacga
gaccuuaaccugcuaaauagcccguauugcuuuggcaguacgcuggcuuc
uuagagggacuaucggcucaagccgauggaaguuugaggcaauaacaggu
cugugaugcccuuagauguucugggccgcacgcgcgcuacacugacacag
ccagcgaguacucccuuggccggaagguccggguaaucuuguuaaacugu
gucgugcuggggauagagcauugcaauuauugcucuucaacgaggaaucc
cuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuugu
acacaccgcccgucgcuacuaccgauugaauggcucagugaggcuuccgg
acuggcccagggaggucggcaacgaccacccagggccggaaagcuaucca
aacucggucauuuagaggaaguaaaagucguaacaaggucuccguuggug
aaccagcggagggaucauu
...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<<...<<.........>>..>>>.>>......<<...
.....<<<..<<..<<....<<<...............<<.....<..<<
<.....>>>..>......>>........<<<<<.......>>>>><...<
<<<<<......[.......<<<<....>>>>..............>>>>>
>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>
>.<<<....<<<......<<<<<<.......>>>>>>..>>>......>>
>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>
.>>.<.<<<..>>>.>...>>>>>>.........<<<....<<<<...>>
>>..>>>..>....>.>....<<<<.<<<<<<..........>>>>>>..
>>>>.....<<..<...........>..>>.........<<<<<((....
..<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>..
.......<<<((.....<.<<...<<<.<<....<<<<<<<<<<<<....
...>>>>>>>>>>>>..<<<..............................
.........>>>....<<<<<<<<.......<<..<<.......>>.<<<
....>>>....>>......>>>>>..>>>.........<<<.<<<<<<<<
<...........].>>>>>>>>>>>>.....>>....<<<<<<.<<...<
<<<..<<..<<<<<<.<...<<<......>>>......>.>>>>>>..>>
.......<<....>>...>>>>...>>>>>.>>>...>>>...>>.>...
.<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.......
...<<<.<<.<<<..<<<<<<<<.<<<<.....>>>>>>>>>>>>..>>>
...<<..))>>...>>.....>>>.>>>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<..<<<.
.......<<........>>..........<<<<<<.....<<<<<.....
...<<.<<<........>>>.>>......>>>>>...<<.<<<..<<.<<
<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>..
..<<<<<.<<..<<<<..<<<<..<<<..........>>>....>>>>..
>>>>.>>....<<<<<<....>>>>>>.......>>>>>....>>>.>>>
.....>>>>>>>.....>>>.>>>......>>>..>>>.....<<<<<<<
......<<.....<<<.<<<<....>>>>.>>>....>>.......>>>>
>>>......<....<<<<<<..........>>>>>>....>.....>>>>
>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<.<..<..
.<<<<<<<.<<<.<<<<<....>>>>>.>>>.>>>>>>>...>..>.>>.
.>>>.>>>>>>>>...>>.>>>>...>.>>...>.....<<<<<<<<<<.
.>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7r81 Structure of the translating Neurospora ribosome arrested by cycloheximide
Resolution2.7 Å
Binding residue
(original residue number in PDB)
G2 R3 G4 P5 K7 H8 K10 L12 S13 L19 K22 L23 V26 Y27 P29 R30 A33 G34 H36 K37 R49 Y58 R59 K62 M66 Q67 K106 R108 R128 L131 G132 K133 G135 V140 T146 R148 K155 G186 R187 D202 F205 A219 R221 K239 R253 R254
Binding residue
(residue number reindexed from 1)
G1 R2 G3 P4 K6 H7 K9 L11 S12 L18 K21 L22 V25 Y26 P28 R29 A32 G33 H35 K36 R48 Y57 R58 K61 M65 Q66 K105 R107 R127 L130 G131 K132 G134 V139 T145 R147 K154 G185 R186 D201 F204 A218 R220 K238 R252 R253
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7r81, PDBe:7r81, PDBj:7r81
PDBsum7r81
PubMed34815343
UniProtQ7SE03

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