Structure of PDB 7pwo Chain F1 Binding Site BS01

Receptor Information
>7pwo Chain F1 (length=161) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLEAYISIDNHSFVPHSAGRWSAKRFRKAKCPVVERLTNSLMMHGRNSGK
KLMAMKTVGEAFELINLYTGKNPVQVLVDAVANSGPREDSCRRQSVDVSP
LRRVNIGIYNIATGARKAAFRKVRPFAECLAEEIMNAAAGADKSYAISQR
NSVERIAVSNR
Ligand information
>7pwo Chain 2 (length=1355) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auccggucgauccugccggagcgcgacgcucuccccaaggacgaagccau
gcaugccucaggacgcggcggacggcucaggacaacgguugcaccccccg
uggcggucgccggacaccgcuggcaacccggcgccaagacgugcgcgcaa
gggcgggccccgggcgagcagcgugacgcagcgacggcccgcccgggcuu
ccggggcaucacccggucggcgcggucgcggcgcgccgagggcccgacgc
cuggcggagaaucaggguucgacuccggagagcgggccugcgagacggcc
cgcacauccaaggacggcagcaggcgcggaacuugcccaaugcgcggcgc
gcggcggcgcgacggggugcgcgcgagucaggcgggcccaccccgacccg
ccagggcaaggcuggugccagcagccgcgguaauuccagcucggcgagcg
ucgcgcggcgcugcugcaguugaaacgcccguaguuggccccccgccgcc
acgaggaaacgggagcgcuccaggcagguuggacccgccgcgugggaccg
cggcgggcccggcgcgccgcggcagccccgaggagagcgggcgggggcac
cgguaccggccggggacgggugaaacaggaugaucccgccgagaccgccg
gccgcgcaggcgccugccaagaccgccucugucaaucaagggcgaaggcc
gggggcuagaaggcgaucagacaccaccguauucccggccguaaacggug
ccgccccgcggccggcgcgcgucccgccggccgcccagggaaaccgggag
gcuccgggcucuggggggaguauggccgcaaggcugaaacuugaaggcau
ugacggagggguacaccagacguggagucugcggcucaaucugacucaac
gcgcgcaccucaccaggcccgcgcgguggugcauggccgcucccagcccg
uggcgcgagccgugcuccauugcgacaacgagcgagaccccggccgcggg
ccgcgggacggcccgcagcgggaggacggcggggcgauagcaggucugug
augcccuccgcccugggccgcacgcgcgcuacacuggcggggccagccgg
cgcccgcgaggacgcgagcccccgccguggccgggaccgcgggcuggaac
gcccccgcgcaccaggaaugucuuguaggcgcccgcccccaccgcgcgcc
ggacgcgucccugccccuuguacacaccgcccgucgcuccuaccgacugg
gcgcugcggcgagcgccccggacgggaagggccgcgagccccagcgccug
gaggaaggagaagucguaacaagguauccguaggugaaccugcggaugga
ucccu
..<<<<<.[..(((>>>>>.<<<<<<<<<..<<<....<......<<<.<
<<..<<<.........>>>......<<........<<<..<<..<<...<
<<<<......<<.....<<<<<<....>>>>>>......>>.....<<..
..<<<.......<.....>..>>>...>>.......>.>>>>..>>>>..
>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>
>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<..........>>>
>>>.<.<<....>>.>...>>>>>>.........<<<....<<<...>>>
..>>>..>.....>>>..........<<<.<<.........>>.>>>..<
<<.<(((...<<<<<.....<<.)))>>.......>>>>>>.>>>..>>>
>>>>>>..........<<<((.....<<<<...<<<.......<<<.<<<
<<<.......<<..<<.......>>........>>.....>>>>>..>.>
>><<<<<<.......>>>.>.>>..........<<<<<<<.....<<<<.
.<<..<<<<<.<<<..<.<......>.>.....>>>.>>>>.>.>>....
...<<....>>...>>>>....>>>>.>>>...>>>...>>>>...<<<<
<<<<...<...<<.<.<.....>.>.>>...>>>>>>>>>.........<
<<.<<..<<<<<<<<<<.<...>.>>>>>>>>>>...<<..))>>....>
>.....>>>.>>>.<<<......<<<<....>>>>....>>>..)))..]
<<<<<.<<<<<<<.<<.<<<<<<..<<<.<<<<<<......<<.......
.>>.........<<<<<.<.....<<.<<<..<<.<<<<<<....<<.<<
<<<<....>>>..<<......>>....>>>.>>....<<<<<.<<<<<<.
>>>>>>.....<<<<<.>>>>>.......>>>>>....>>>.>>>.....
>>>>>>>..>.>>>>>...>>.>>>>.>>>.....<<<<<<<.......<
<<.<<....>>.>>>....>>>>>>>......<....<<.<<<<......
>>>>.>>....>.....>>>>>>....<<<<<.<<.......>>.>>>>>
......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<
<<<<<<.<<<..<<<.<<<.........>>>.>>>..>>>.>>>>>>>>.
..>>.>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>...
.....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pwo Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		H37 S43 K45 R46 K49 N60 M63 H65 G66 R67 N68 S69 G70 M74 K77 N134 Y138 R145 F149 R150 K151 V152 F155
Binding residue
(residue number reindexed from 1)		H16 S22 K24 R25 K28 N39 M42 H44 G45 R46 N47 S48 G49 M53 K56 N105 Y109 R116 F120 R121 K122 V123 F126
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwo, PDBe:7pwo, PDBj:7pwo
PDBsum7pwo
PubMed35100413
UniProtA8BZD3

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