Structure of PDB 8v4x Chain F Binding Site BS01

Receptor Information

>8v4x Chain F (length=358) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QPLAKDKVALLIGNMNYREHPKLKAPLVDVYELTNLLRQLDFKVVSLLDL
TEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRS
ENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTPILDALKVTANIV
FGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMG
KCHLTKGKQALEIRSSLSEKRALTDPIQVRNLQWAKAHELPESMCLKFDC
GVQIQLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDA
NKGTPEETGSYLHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQ
EVNVGKPL

Ligand information

>8v4x Chain L (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tVRPR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8v4x Inhibition of MALT1 and BCL2 induces synergistic anti-tumor activity in models of B cell lymphoma.
Resolution	2.486 Å
Binding residue (original residue number in PDB)	K358 L359 D365 G414 H415 D462 C464 A498 F499 E500 I501 Q502 L541
Binding residue (residue number reindexed from 1)	K22 L23 D29 G78 H79 D126 C128 A161 F162 E163 I164 Q165 L204

Enzymatic activity

Enzyme Commision number

3.4.22.-

Gene Ontology

	Molecular Function
GO:0004197	cysteine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:8v4x, PDBe:8v4x, PDBj:8v4x
PDBsum	8v4x
PubMed	38507740
UniProt	Q9UDY8\|MALT1_HUMAN Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (Gene Name=MALT1)

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