Structure of PDB 8qzs Chain F Binding Site BS01

Receptor Information
>8qzs Chain F (length=404) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNIL
SVVNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSL
RSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHT
LRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVAD
IEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGV
YDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN
GYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTG
AYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKL
WMAE
Ligand information
>8qzs Chain 4 (length=136) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agcuuugcgcaguggcaguaucguagccaaugaggucuauccgaggcgcg
auuauugcuaauuacuuuucccaauaccccgccgugacgacuugcaauau
agucggcacuggcaauuuuugacagucucgagacug
...................<<<<<.<<<.....<<.....>>..>>>>>>
>>............................<<<<<<.<<<<<........
>>>>>.>>>.>>>.........<<<<<<..>>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8qzs Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution4.1 Å
Binding residue
(original residue number in PDB)		P126 A127
Binding residue
(residue number reindexed from 1)		P39 A40
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030621 U4 snRNA binding
Biological Process
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0015030 Cajal body
GO:0016607 nuclear speck
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071001 U4/U6 snRNP
GO:0071005 U2-type precatalytic spliceosome
GO:0097525 spliceosomal snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qzs, PDBe:8qzs, PDBj:8qzs
PDBsum8qzs
PubMed38778104
UniProtO43172|PRP4_HUMAN U4/U6 small nuclear ribonucleoprotein Prp4 (Gene Name=PRPF4)

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