Structure of PDB 8qof Chain F Binding Site BS01

Receptor Information

>8qof Chain F (length=493) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PYRTTVEIGLILYGIIYYLSKPQQKKSLSPQEIDALIEDWEPEPLVDPSA
TDEQSWRVAKTPVTMEMPIQNHITITRNNLQEKYTNVFNLASNNFLQLSA
TEPVKEVVKTTIKNYGVGACGPAGFYGNQDVHYTLEYDLAQFFGTQGSVL
YGQDFCAAPSVLPAFTKRGDVIVADDQVSLPVQNALQLSRSTVYYFNHND
MNSLECLLNELTEQEKLEKLPAIPRKFIVTEGIFHNSGDLAPLPELTKLK
NKYKFRLFVDETFSIGVLGATGRGLSEHFNMDRATAIDITVGSMATALGS
TGGFVLGDSVMCLHQRIGSNAYCFSACLPAYTVTSVSKVLKLMDSNNDAV
QTLQKLSKSLHDSFASDDSLRSYVIVTSSPVSAVLHLQLTPAYRSRKFGY
TCEQLFETMSALQKKSQTNKFIEPYEEEEKFLQSIVDHALINYNVLITRN
TIVLKQETLPIVPSLKICCNAAMSPEELKNACESVKQSILACC

Ligand information

Ligand ID

PLP

InChI

InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)

InChIKey

NGVDGCNFYWLIFO-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0	Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04	O=P(O)(O)OCc1cnc(c(O)c1C=O)C

Formula

C8 H10 N O6 P

Name

PYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate

PDB chain

8qof Chain G Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8qof The structure of the Orm2-containing serine palmitoyltransferase complex reveals distinct inhibitory potentials of yeast Orm proteins.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	S385 A386
Binding residue (residue number reindexed from 1)	S325 A326
Annotation score	1

External links

PDB	RCSB:8qof, PDBe:8qof, PDBj:8qof
PDBsum	8qof
PubMed	39167489
UniProt	P25045\|SPTC1_YEAST Serine palmitoyltransferase 1 (Gene Name=LCB1)

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