Structure of PDB 8poh Chain F Binding Site BS01

Receptor Information

>8poh Chain F (length=623) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))

MDVNPTLLFLKVPVQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHKYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEIVQQTRVDKLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMDSMDKEEMEITTKKKQRLNKRSYLIRALT
LNTMTKDAERGKLKRRAIATPGMQIRGFVYFVEALARSICEKLEQSGLPV
GGNEKKAKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMIT
YITRNQPEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQVPAEML
ANIDLKYFNKSTREKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSI
LNLGQKKYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLV
GINMSKKKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADM
SVGVTVIKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRA
FELKKLWEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGR
LCNPMNPFVSDAVATTHSWIPKR

Ligand information

>8poh Chain U (length=14)

aguagaaacaaggg

.<<....>>.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8poh The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): H32 R365
• Binding residue (residue number reindexed from 1): H32 R342

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0005737 cytoplasm
• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:8poh, PDBe:8poh, PDBj:8poh
• PDBsum: 8poh
• PubMed: 38316757
• UniProt: M9TLW3