Structure of PDB 8osg Chain F Binding Site BS01

Receptor Information
>8osg Chain F (length=258) Species: 103690 (Nostoc sp. PCC 7120 = FACHB-418) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVFPFTAIVGQEEMKLALLLNVIDPKIGGVMIMGDRGTGKSTTIRALADL
LPIEFKMVDLLAKANRGILYVDEVNLLDDHLVDVLLDSAASGARFVLVGS
GNPEEGELRPQLLDRFGMHAEIHTVKEPALRVQIVEQRSEFDQNPPTFLE
KYNPEQTALQKKIVEAQKLLPEVKLDYDLRVKISEVCSELDVDGLRGDIV
TNRAAKALTAYEGRTEVTVDDIRRVITLCLRHRLRKDPLESIDSGYKVEK
VFARIFGV
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain8osg Chain F Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8osg Conformational variability of cyanobacterial ChlI, the AAA+ motor of magnesium chelatase involved in chlorophyll biosynthesis.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		I21 R49 G50 T51 G52 K53 S54 T55 I229 R233
Binding residue
(residue number reindexed from 1)		I8 R36 G37 T38 G39 K40 S41 T42 I134 R138
Annotation score5
Enzymatic activity
Enzyme Commision number 6.6.1.1: magnesium chelatase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016851 magnesium chelatase activity
GO:0016874 ligase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0015979 photosynthesis
GO:0015995 chlorophyll biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8osg, PDBe:8osg, PDBj:8osg
PDBsum8osg
PubMed37737632
UniProtP58571|CHLI_NOSS1 Magnesium-chelatase subunit ChlI (Gene Name=chlI)

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