Structure of PDB 8ecy Chain F Binding Site BS01

Receptor Information
>8ecy Chain F (length=371) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATSASSHLNKGIKQVYMALPQGDKVQAMYIWIDGTGEGLRCKTRTLDSEP
KCIEELPEWNFDGSSTFQSEGSNSDMYLVPAAMFRDPFRKDPNKLVFCEV
FKYNRKPAETNLRHTCKRIMDMVSNQRPWFGMEQEYTLMGTDGHPFGWPS
NGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKIGGTNAEVMPAQ
WEFQIGPCEGIDMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAG
CHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLT
GFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPFAV
TEALIRTCLLNETGDEPFQYK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8ecy Chain F Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ecy Bestrophin-2 and glutamine synthetase form a complex for glutamate release.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E136 E196 E203
Binding residue
(residue number reindexed from 1)		E135 E195 E202
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.225: protein S-acyltransferase.
6.3.1.2: glutamine synthetase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004356 glutamine synthetase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016874 ligase activity
GO:0019706 protein-cysteine S-palmitoyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006542 glutamine biosynthetic process
GO:0010594 regulation of endothelial cell migration
GO:0018345 protein palmitoylation
GO:1903670 regulation of sprouting angiogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ecy, PDBe:8ecy, PDBj:8ecy
PDBsum8ecy
PubMed36289327
UniProtP15103|GLNA_BOVIN Glutamine synthetase (Gene Name=GLUL)

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