Structure of PDB 8dy7 Chain F Binding Site BS01

Receptor Information

>8dy7 Chain F (length=301) Species: 54571 (Streptomyces venezuelae)

ATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANSDKLAPK
LKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNL
GLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVI
NKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTP
LGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVS
MRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDY
L

Ligand information

>8dy7 Chain O (length=78)

ccagatcgtgcgacacaccgggccaattggccgatgccgtcccgcgaacc
cctctaccgtgttgagcagcagcggcct

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8dy7 Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.
• Resolution: 3.18 Å
• Binding residue (original residue number in PDB): L223 I226 G227 R288 K295 K321 Y328 K329 S331 T332 Y333 T335 W336 W337 Q340 R344 R354 H358 E488 R489 Q492 K496
• Binding residue (residue number reindexed from 1): L10 I13 G14 R75 K82 K108 Y115 K116 S118 T119 Y120 T122 W123 W124 Q127 R131 R141 H145 E275 R276 Q279 K283

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity
• GO:0016987 sigma factor activity

Biological Process

• GO:0006352 DNA-templated transcription initiation
• GO:0006355 regulation of DNA-templated transcription
• GO:0010468 regulation of gene expression
• GO:2000142 regulation of DNA-templated transcription initiation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8dy7, PDBe:8dy7, PDBj:8dy7
• PDBsum: 8dy7
• PubMed: 36888660
• UniProt: F2R7X6