Structure of PDB 8d1x Chain F Binding Site BS01

Receptor Information

>8d1x Chain F (length=469) Species: 521006 (Neisseria gonorrhoeae NCCP11945)

HMEFSTKTEILQEQQAGAQLFVCADKAPEHNTAAHALFSALEEGQNFSDT
KIPTDNGLQAVAVVRLEKTDRAALNKAAAEAAKWAQNQETVNVDVHAFDE
AQAAAVAEAFAIAFGNAAYRFDRYKKEAKPAKFSQAVFHSAHEAAVKEAL
RVAEAQVYGQSLCRDLGNAAPNECTPEFLARTAKAEAEKLGAHAKIIEKD
YIKENMGSFWSVAKGSVEDPYLVELSYFGAADKEAAPVVLVGKGITFDTG
GISLKPGLNMDEMKFDMCGAATVISTFCAAVKLQLPINLIAIVATCENMP
SGAANKPGDVVKSMKGLTIEVLNTDAEGRLILCDALTYAEQFKPKAVIDV
ATLTGACIVALGHDVSGVMGNNQDLIDSLLAASYNVDDKAWQLPLFETYK
DQLKSNFADIPNIGTPGAGTITAATFLSYFTEGYPWAHLDIAGTAWKSGA
EKGATGRPVPLLMNYLRNL

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 8d1x Chain F Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d1x Crystal Structure of aminopeptidase A from Neisseria gonorrhoeae
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): D247 K254 D324 E326
• Binding residue (residue number reindexed from 1): D248 K255 D325 E327
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.4.11.1: leucyl aminopeptidase.
  3.4.11.10: bacterial leucyl aminopeptidase.

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8d1x, PDBe:8d1x, PDBj:8d1x
• PDBsum: 8d1x
• UniProt: B4RJ22