Structure of PDB 8d0k Chain F Binding Site BS01

Receptor Information
>8d0k Chain F (length=915) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETH
VSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIAT
KYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETF
SHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKP
DLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKA
APKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFL
AKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKL
GGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVI
PMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAG
NIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQGLVLDPKVGFYDKFIL
LLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLE
MGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMY
GCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIM
INTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAA
LVVEPTSDGNYVTKQELKQLTDEEKYRDCERFKCPCPTCGTENIYDNVFD
GSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLI
CEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRY
IFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYS
EVNLSKLFAGCAVKS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d0k Structures of the human CST-Pol alpha-primase complex bound to telomere templates.
Resolution4.27 Å
Binding residue
(original residue number in PDB)		Q554 V653 K655 K672
Binding residue
(residue number reindexed from 1)		Q231 V330 K332 K349
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0000731 DNA synthesis involved in DNA repair
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0032479 regulation of type I interferon production
GO:1902975 mitotic DNA replication initiation
GO:1904161 DNA synthesis involved in UV-damage excision repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005658 alpha DNA polymerase:primase complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016363 nuclear matrix
GO:0031981 nuclear lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8d0k, PDBe:8d0k, PDBj:8d0k
PDBsum8d0k
PubMed35830881
UniProtP09884|DPOLA_HUMAN DNA polymerase alpha catalytic subunit (Gene Name=POLA1)

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