Structure of PDB 8cgr Chain F Binding Site BS01

Receptor Information
>8cgr Chain F (length=103) Species: 679895 (Escherichia coli BW25113) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRHYEIVFMVHPDQSEQVPGMIERYTAAITGAEGKIHRLEDWGRRQLAYP
INKLHKAHYVLMNVEAPQEVIDELETTFRFNDAVIRSMVMRTKHAVTEAS
PMV
Ligand information
>8cgr Chain A (length=1060) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aaauugaagaguuugaucauggcucagauugaacgcuggcggcaggccua
acacaugcaagucgaacgguaacaggaagaagcuugcuucuuugcugacg
aguggcggacgggugaguaaugucugggaaacugccugauggagggggau
aacuacuggaaacgguagcuaauaccgcauaacgucgcaagaccaaagag
ggggccucuugccaucggaugugcccagaugggauuagcuaguagguggg
guaacggcucaccuaggcgacgaucccuagcuggucugagaggaugacca
gccacacuggaacugagacacgguccagacuccuacgggaggcagcagug
gggaauauugcacaaugggcgcaagccugaugcagccaugccgcguguau
gaagaagcccuucggguuguaaaguacuuucagcggggaggaagggagua
aaguuaauaccuuugcucauugacguuacccgcagaagaagcaccggcua
acuccgugccagcagccgcgguaauacggagggugcaagcguuaaucgga
auuacugggcguaaagcgcacgcaggcgguuuguuaagucagaugugaaa
uccccgggcucaaccugggaacugcaucugauacuggcaagcuugagucu
cguagagggggguagaauuccagguguagcggugaaaugcguagagaucu
ggaggaauaccgguggcgaaggcggcccccuggacgaagacugacgcuca
ggugcgaaagcguggggagcaaacaggauuagauacccugguaguccacg
ccguaaacgaugucgacuuggagguugugccggcguggcuuccggagcua
acgcguuaagucgaccgccuggggaguacggccgcaagguuaaaacucaa
augaauugacggggguuguacacaccgcccgucacaccaugggagugggu
ugcaaaagaaguagguagcuuaaccuucgggagggcgcuuaccacuuugu
gauucaugacuggggugaagucguaacaagguaaccguaggggaaccugc
gguuggauca
........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<....
.<<<.<<<..<<<..<<.<<..<<<<<<<<.<....>.>>>>>.>>>>>.
.>>>>>......<<.......<<<<<<<..<<...<<<<<<<.<.<<...
..<<<<<......>>>>>......>>.>.....<<<....>>>....<<<
<<<.>>>>>>.>>>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.
........>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>
>>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>
.........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<
.....<<<<.....>>>>.....>>>>...<.<<<<<......<.<<<<<
<<<.<...>.>>>>>>>>.>........>>>>>....>..<<<<<(((..
.<<<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>...
.......<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<....
..<<<<<<.....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<
<<<...<<<<<<<....<<<<<<<<...<<<......>>>......>>>>
>>>>...........<<....>>.>>>>>>>..>>>>.>>>>...>>>..
.>>>>....<<<<<<...<<...<<<<.........>>>>...>>>>>>>
>..........<<<<<<.<<<<<<<<<<<<..>>>>>>>>>>>>..<<..
))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>>..
)))).]<<<<<.....>>>.>>....<..<<.<.<<<<.<<<..<<<<<<
<<<<<<....<<<<<<.<<<<..<<<..>>>.>>>>>>>>>>...>>>>>
>>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>
>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cgr Structural conservation of antibiotic interaction with ribosomes.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		R2 Y4 Y49 K53 Q68 R79 R86 V89 M90 R91 K93
Binding residue
(residue number reindexed from 1)		R2 Y4 Y49 K53 Q68 R79 R86 V89 M90 R91 K93
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0048027 mRNA 5'-UTR binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cgr, PDBe:8cgr, PDBj:8cgr
PDBsum8cgr
PubMed37550453
UniProtP02358|RS6_ECOLI Small ribosomal subunit protein bS6 (Gene Name=rpsF)

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