Structure of PDB 8cah Chain F Binding Site BS01

Receptor Information
>8cah Chain F (length=141) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVPSVQTFGKKKSATAVAHVKAGKGLIKVNGSPITLVEPEILRFKVYEPL
LLVGLDKFSNIDIRVRVTGGGHVSQVYAIRQAIAKGLVAYHQKYVDEQSK
NELKKAFTSYDRTLLIADSRRPEPKKFGGKGARSRFQKSYR
Ligand information
>8cah Chain 2 (length=1745) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuacaugguauaacugugguaau
ucuagagcuaauacaugcuuaaaaucucgacccuuuggaagagauguauu
uauuagauaaaaaaucaaugucuucggacucuuugaugauucauaauaac
uuuucgaaucgcauggccuugugcuggcgaugguucauucaaauuucugc
ccuaucaacuuucgaugguaggauaguggccuaccaugguuucaacgggu
aacggggaauaaggguucgauuccggagagggagccugagaaacggcuac
cacauccaaggaaggcagcaggcgcgcaaauuacccaauccuaauucagg
gagguagugacaauaaauaacgauacagggcccauucgggucuuguaauu
ggaaugaguacaauguaaauaccuuaacgaggaacaauuggagggcaagu
cuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaagu
uguugcaguuaaaaagcucguaguugaacuuugggcccgguuggccgguc
ggauuuccaacggggccuuuccuucuggcuaaccuugagcuuggcgaacc
aggacuuuuacuuugaaaaaauuagaguguucaaagcaggcguauugcuc
gaauauauuagcauggaauaauagaauaggacguuugguucuauuuuguu
gguuucuaggaccaucguaaugauuaauagggacggucgggggcaucagu
auucaauugucagaggugaaauucuuggauuuauugaagacuaacuacug
cgaaagcauuugccaaggacguuuucauuaaucaagaacgaaaguuaggg
gaucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccga
cuagggaucgggugguguuuuuuuaaugacccacucggcaccuuacgaga
aaucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuu
aaaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauu
ugacucaacacggggaaacucaccagguccagacacaauaaggauugaca
gauugagagcucuuucuugauuuugugggugguggugcauggccguucuu
aguugguggagugauuugucugcuuaauugcgauaacgaacgagaccuua
accuacuaaauaguggugcuagcauuugcugguuauccacuucuuagagg
gacuaucgguuucaagccgauggaaguuugaggcaauaacaggucuguga
ugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcg
agucuaaccuuggccgagaggucuugguaaucuugugaaacuccgucgug
cuggggauagagcauuguaauuauugcucuucaacgaggaauuccuagua
agcgcaagucaucagcuugcguugauuacgucccugcccuuuguacacac
cgcccgucgcuaguaccgauugaauggcuuagugaggccucaggaucugc
uuagaucagagcggagaauuuggacaaacuuggucauuuagaggaacuaa
aagucguaacaagguuuccguaggugaaccugcggaaggaucauu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<..........<.....<<.<<<....
.>>>.>>......>.........<<<<<..<<....>>..>>>>><...<
<<<<<......(((.{((.........................>>>>>>.
....>...<<<<..<<<.....>>>.>>>>....>>>...>>>>..>>>.
<<<....<<<....<<<<<<<<.......>>>>>>>>>>>......>>>.
..<<<.<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>
>.<.<<....>>.>...>>>>>>.........<<<....<<<.....>>>
..>>>..>....>.>.....<<<<<<<...<<......>>...>>>>.>>
>......<<..<...........>..>>.........<<<<<((......
<<<<.....<<..))>>.......>>>>.>>>>>..>>>>>>>>>>....
.....<<<[[.....<.<<...<<<.<<....<<<<<<.<<<<<......
....>..>>>>.>>>>>>.....<<<<<....................>>
>>>....<<<<<.<<.......<<...<.......>..<<<.....>>>.
...>>......>>.>>..>>>.........<<<..<<<<<<<<.....))
.}))).>>>>>>>>.>>>.....>>....<<<<<<.<<...<<<<..<<.
.<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<
<....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<
<.<<<..<<<<<<<<.<<<........>>>>>>>>>>>..>>>...<<..
]]>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>
..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......
<<........>>..........<<<<<.<....<<<<<........<<.<
<<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<<...
.<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<
.<<..<<<<..<<<<<.<<<<<<....>>>>>>...>>>>>..>>>>.>>
....<<<<<<.....>>>>>>.......>>>>>....>>>.>>>.....>
>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......
<<.....<<..<<<<....>>>>..>>....>>.......>>>>>>>...
...<....<<<<<<..........>>>>>>....>.....>>>>>>....
<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>...
.<..<<.<..<<<<.<<....<<<<<<<<.<<<..<.<<..<...<<<<<
<<.<..>.>>>>>>>...>..>>.>..>>>.>>>>>>>>...>>.>>>>.
..>.>>...>.....<<<<<<<<<<..>>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cah Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Resolution3.0 Å
Binding residue
(original residue number in PDB)
Q8 F10 K14 S15 V19 K30 E40 E42 R66 G71 G72 G73 H74 V75 S76 Q77 R114 I118 S121 R122 R123 P124 E125 P126 K127 K128 F129 G130 G133 R135 S136 R137 F138 Q139 K140 S141 Y142 R143
Binding residue
(residue number reindexed from 1)
Q6 F8 K12 S13 V17 K28 E38 E40 R64 G69 G70 G71 H72 V73 S74 Q75 R112 I116 S119 R120 R121 P122 E123 P124 K125 K126 F127 G128 G131 R133 S134 R135 F136 Q137 K138 S139 Y140 R141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8cah, PDBe:8cah, PDBj:8cah
PDBsum8cah
PubMed37169754
UniProtP0CX51|RS16A_YEAST Small ribosomal subunit protein uS9A (Gene Name=RPS16A)

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