Structure of PDB 7x75 Chain F Binding Site BS01

Receptor Information
>7x75 Chain F (length=301) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATADPVKDYLKQIGKVPLLNAEQEVELAKRIEAGLFAEDKLANSDKLAPK
LKRELEIIAEDGRRAKNHLLEANLRLVVSLAKRYTGRGMLFLDLIQEGNL
GLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVEVI
NKLARVQRQMLQDLGREPTPEELAKELDMTPEKVIEVQKYGREPISLHTP
LGEDGDSEFGDLIEDSEAVVPADAVSFTLLQEQLHSVLDTLSEREAGVVS
MRFGLTDGQPKTLDEIGKVYGVTRERIRQIESKTMSKLRHPSRSQVLRDY
L
Ligand information
>7x75 Chain O (length=84) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaggcacatgacaacggtgttcagtgccgcgttgcccgataccccctac
ccgtagttgactggcatccgggcgccgggtcgcc
Receptor-Ligand Complex Structure
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PDB7x75 Structural basis of Streptomyces transcription activation by zinc uptake regulator.
Resolution3.45 Å
Binding residue
(original residue number in PDB)		V215 K216 L219 L227 A281 N282 R284 L285 K291 F300 R313 K317 K322 Y324 K325 S327 T328 T331 W332 W333 Q336 R340 R350 P352 H354 T482 E484 R485 Q488
Binding residue
(residue number reindexed from 1)		V6 K7 L10 L18 A72 N73 R75 L76 K82 F91 R104 K108 K113 Y115 K116 S118 T119 T122 W123 W124 Q127 R131 R141 P143 H145 T273 E275 R276 Q279
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001108 bacterial-type RNA polymerase holo enzyme binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7x75, PDBe:7x75, PDBj:7x75
PDBsum7x75
PubMed35871291
UniProtP18183|SIGA_STRCO RNA polymerase principal sigma factor HrdB (Gene Name=hrdB)

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