Structure of PDB 7wm4 Chain F Binding Site BS01

Receptor Information

>7wm4 Chain F (length=668) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQ
LAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLT
ELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQEL
LLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFAL
LLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNL
TQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRY
LSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFT
GLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGT
FSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSF
ALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLL
EGLENLEILDFQHNNLARLWNPGGPVNFLKGLSHLHILNLESNGLDEIPV
GVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDV
FGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNT
PHHYYGFPLKLFDTSSCK

Ligand information

>7wm4 Chain A (length=81) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

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Receptor-Ligand Complex Structure

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Structure summary

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PDB	7wm4 TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	H40 K42 H61 N62 Q63 F85 N86 S87 E111 R545 K620
Binding residue (residue number reindexed from 1)	H13 K15 H34 N35 Q36 F58 N59 S60 E84 R518 K590

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:7wm4, PDBe:7wm4, PDBj:7wm4
PDBsum	7wm4
PubMed	36631495
UniProt	Q99MB1\|TLR3_MOUSE Toll-like receptor 3 (Gene Name=Tlr3)

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