Structure of PDB 7w5x Chain F Binding Site BS01

Receptor Information
>7w5x Chain F (length=495) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGIN
QVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPEL
AREKFAELRAQYVVTRDTIKAKGRSHATAQEEILKLSEVFKQFRLVPKQF
DYLVNSMRVMMDRVRTQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWF
NAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMS
IGEAKARRAKKEMVEANLRLVISIAKKYTRGLQFLDLIQEGNIGLMKAVD
KFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRIS
RQMLQEMGREPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDS
HLGDFIEDTTLELPLDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDM
NTDYTLEEVGKQFDVTRERIRQIEAKALRKLRPSRSEVLRSFLDD
Ligand information
>7w5x Chain 1 (length=75) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcgcacgggtggataagcgtttacagttttcgcaagctcgtaaaagcag
tataatgggagctgtcacggatgca
Receptor-Ligand Complex Structure
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PDB7w5x Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D96 R99 M102 G106 L110 N383 R385 L386 I388 K418 F419 E420 R423 Y425 K426 S428 T429 Y430 T432 W433 Q437 R451 P453 H455 T583 E585 R586
Binding residue
(residue number reindexed from 1)		D18 R21 M24 G28 L32 N267 R269 L270 I272 K301 F302 E303 R306 Y308 K309 S311 T312 Y313 T315 W316 Q320 R334 P336 H338 T466 E468 R469
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5x, PDBe:7w5x, PDBj:7w5x
PDBsum7w5x
PubMed36243985
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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