Structure of PDB 7w5w Chain F Binding Site BS01

Receptor Information
>7w5w Chain F (length=481) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAEEARLSDLITGFVDPNAENSIDPELAREKFAELRAQYVV
TRDTIKAKGRSHATAQEEILKLSEVFKQFRLVKQFDYLVNSMRVMMDRVR
TQERLIMKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLH
DVSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVE
ANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYA
TWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPE
ELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELP
LDSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFD
TRERIRQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>7w5w Chain 1 (length=63) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acagcactgaatgtcaaaacaaaaccttcactcgcaactataatgggagc
tgtcacggatgca
Receptor-Ligand Complex Structure
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PDB7w5w Structural basis of three different transcription activation strategies adopted by a single regulator SoxS.
Resolution4.55 Å
Binding residue
(original residue number in PDB)		V98 R99 M102 L110 N383 R385 K392 F401 E420 R423 Y425 K426 S428 T429 Y430 T432 W433 Q437 R451 R586
Binding residue
(residue number reindexed from 1)		V6 R7 M10 L18 N252 R254 K261 F270 E289 R292 Y294 K295 S297 T298 Y299 T301 W302 Q306 R320 R454
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5w, PDBe:7w5w, PDBj:7w5w
PDBsum7w5w
PubMed36243985
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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