Structure of PDB 7v96 Chain F Binding Site BS01

Receptor Information

>7v96 Chain F (length=87) Species: 9606 (Homo sapiens)

KRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENV
IRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Ligand information

>7v96 Chain I (length=275)

gggttagggttagggttagggttagggttagggttagggttagggttagg
gttagggttagggttagggttagggttagggttagggttagggttagggt
tagggttagggttagggttagggttagggttagggttagggttagggtta
gggttagggttagggttagggttagggttagggttagggttagggttagg
gttagggttagggttagggttagggttagggttagggttagggttagggt
tagggttagggttagggttagggtt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7v96 Columnar structure of human telomeric chromatin.
• Resolution: 3.92 Å
• Binding residue (original residue number in PDB): R35 R45 I46 S47 K79
• Binding residue (residue number reindexed from 1): R20 R30 I31 S32 K64

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0005515 protein binding
• GO:0030527 structural constituent of chromatin
• GO:0046982 protein heterodimerization activity

Biological Process

• GO:0006325 chromatin organization
• GO:0006334 nucleosome assembly
• GO:0032200 telomere organization
• GO:0045653 negative regulation of megakaryocyte differentiation
• GO:0061644 protein localization to CENP-A containing chromatin

Cellular Component

• GO:0000781 chromosome, telomeric region
• GO:0000786 nucleosome
• GO:0005576 extracellular region
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005694 chromosome
• GO:0016020 membrane
• GO:0032991 protein-containing complex
• GO:0043505 CENP-A containing nucleosome
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:7v96, PDBe:7v96, PDBj:7v96
• PDBsum: 7v96
• PubMed: 36104563
• UniProt: P62805|H4_HUMAN Histone H4 (Gene Name=H4C1)