Structure of PDB 7uix Chain F Binding Site BS01

Receptor Information
>7uix Chain F (length=571) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFTTNLNQLARVGGIDPLIGREKELERAIQVLCRRRKNNPLLVGESGVGK
TAIAEGLAWRIVQGDVPEVMADCTIYSLDIGSLLAGTKYRGDFEKRFKAL
LKQLEQDTNSILFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKIRVIG
STTYQEFSNIFEKDRALARRFQKIDITEPSIEETVQIINGLKPKYEAHHD
VRYTAKAVRAAVELAVKYINDRHLPDKAIDVIDEAGARARLMPVSKRKKT
VNVADIESVVARIARIPEKSVSQSDRDTLKNLGDRLKMLVFGQDKAIEAL
TEAIKMARAGLGHEHKPVGSFLFAGPTGVGKTEVTVQLSKALGIELLRFD
MSEYMERHTVSRLIGAPPGYVGFDQGGLLTDAVIKHPHAVLLLDEIEKAH
PDVFNILLQVMDNGTLTDNNGRKADFRNVVLVMTTNTERKSIGLIHQDNS
TMEEIKKIFTPEFRNRLDNIIWFDHLSTDVIHQVVDKFIVELQVQLDQKG
VSLEVSQEARNWLAEKGYDRAMGARPMARVIQDNLKKPLANELLFGSLVD
GGQVTVALDKEKNELTYGFQS
Ligand information
>7uix Chain S (length=25) Species: 562 (Escherichia coli) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GKTNDWLDFDQLAEEKVRDALKPPS
Receptor-Ligand Complex Structure
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PDB7uix AAA+ protease-adaptor structures reveal altered conformations and ring specialization.
Resolution3.24 Å
Binding residue
(original residue number in PDB)		K258 Y259 R260 S297 G298 Y540 V541
Binding residue
(residue number reindexed from 1)		K88 Y89 R90 S127 G128 Y370 V371
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006508 proteolysis
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006979 response to oxidative stress
GO:0034605 cellular response to heat
GO:0043335 protein unfolding
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009368 endopeptidase Clp complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uix, PDBe:7uix, PDBj:7uix
PDBsum7uix
PubMed36329286
UniProtP0ABH9|CLPA_ECOLI ATP-dependent Clp protease ATP-binding subunit ClpA (Gene Name=clpA)

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