Structure of PDB 7u6e Chain F Binding Site BS01

Receptor Information
>7u6e Chain F (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLG
LIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR
QLWDWSKHNLTTTQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL
KTNGDKASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKE
APYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPW
TQYAIFVKTLVTFSTYGAKSDIIYVQTDASQILKELEESSFRKTFEDYLH
NVVFVPRP
Ligand information
>7u6e Chain A (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
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PDB7u6e Activation of the human insulin receptor by non-insulin-related peptides
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D707 H710 N711 F714 V715 P716 R717
Binding residue
(residue number reindexed from 1)		D297 H300 N301 F304 V305 P306 R307
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7u6e, PDBe:7u6e, PDBj:7u6e
PDBsum7u6e
PubMed36171189
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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