Structure of PDB 7ttw Chain F Binding Site BS01

Receptor Information

>7ttw Chain F (length=87) Species: 1280 (Staphylococcus aureus)

RDILKRPVITEKSSEAMAEDKYTFDVDTRVNKTQVKMAVEEIFNVKVASV
NIMNYKPKKKRMGRYQGYTNKRRKAIVTLKEGSDDLF

Ligand information

>7ttw Chain 1 (length=2690)

uaaguuauuaagggcgcacgguggaugccuuggcacuagaagccgaugaa
ggacguuacuaacgacgauaugcuuuggggagcuguaaguaagcuuugau
ccagagauuuccgaauggggaaacccagcaugaguuaugucauguuaucg
auaugugaauacauagcauaucagaaggcacacccggagaacugaaacau
cuuaguacccggaggaagagaaagaaaauucgauucccuuaguagcggcg
agcgaaacgggaagagcccaaaccaacguugggguuguaggacacucuag
uuacaaaggacgacauuagacgaaucaucuggaaagaugaaucaaagaag
guaauaauccuguagucgaaaauguugucucucuugaguggauccugagu
acgacggagcacgugaaauuccgucggaaucugggaggaccaucuccuaa
ggcuaaauacucucuagugaccgauagugaaccaguaccgugagggaaag
gugaaaagcaccccggaaggggagugaaauagaaccugaaaccgugugcu
uacaaguagucagagcccguuaaugggugauggcgugccuuuuguagaau
gaaccggcgaguuacgauuugaugcaagguuaagcaguaaauguggagcc
guagcgaaagcgagucugaauagggcguuuaguauuuggucguagacccg
aaaccaggugaucuacccuuggucagguugaaguucagguaacacugaau
ggaggaccgaaccgacuuacguugaaaagugagcggaugaacugagggua
gcggagaaauuccaaucgaaccuggagauagcugguucucuccgaaauag
cuuuagggcuagccucaagugaugauuauuggagguagagcacuguuugg
acuucagacaaacuccgaaugccaauuaauuuaacuugggagucagaaca
ugggugauaagguccguguucgaaagggaaacagcccagaccaccagcua
aggucccaaaauauauguuaaguggaaaaggauguggcguugccacagag
ugacacugcgccgaaaauguaccggggcuaaacauauuaccgaagcugug
gauuguccuuuggacaaugguaggagagcguucuaagggcguugaagcau
gaucguaaggacauguggagcgcuuagaagugagaaugccggugugagua
gcgaaagacgggugagaaucccguccaccgauugacuaagguuuccagag
gaaggcucguccgcucuggguuagucggguccuaagcugaggccgacagg
cguaggcgauggauaacagguugauauuccuguaccaccuauaaucguau
cgauggggggacgcaguaggauaggcgaagcgugcgauuggauugcacgu
cuaagcaguaaggcugccgguagcugagcugugauggggagaagaccuuc
gagucguugauuucacacugccgagaaaagccucuagauagaaaauaggu
gcccguaccgcaaaccgacacagguagucaagaugagaauucuaagguga
gcgagcgaacucucguuaaggaacucggcaaaaugaccccguaacuucgg
gagaaggggugcucuuuaggguuaacgcccagaagagccgcagugaauag
gcccaagcgacuguuuaucaaaaacacaggucucugcuaaaccguaaggu
gauguauaggggcugacgccugcccggugcuggaagguuaagaggagugg
uuagcuucugcgaagcuacgaaucgaagccccaguaaacggcggccguaa
cuauaacgguccuaagguagcgaaauuccuugucggguaaguuccgaccc
gcacgaaaggcguaacgauuugggcacugucucaacgagagacucgguga
aaucauaguaccugugaagaugcagguuacccgcgacaggacggaaagac
cccguggagcuuuacuguagccugauauugaaauucggcuuucuaacccg
caccacuuaucguggugggagacagugucaggcgggcaguuugacugggg
cggucgccuccuaaaagguaacggaggcgcucaaagguucccucagaaug
guuggaaaucauucauagaguguaaaggcauaagggagcuugacugcgag
accuacaagucgagcagggucgaaagacggacuuagugauccggugguuc
cgcauggaagggccaucgcucaacggauaaaagcuaccccggggauaaca
ggcuuaucucccccaagaguucacaucgacggggagguuuggcaccucga
ugucggcucaucgcauccuggggcuguagucggucccaaggguugggcug
uucgcccauuaaagcgguacgcgagcuggguucagaacgucgugagacag
uucggucccuauccgucgugggcguaggaaauuugagaggagcuguccuu
aguacgagaggaccgggauggacauaccucugguguaccaguugucgugc
caacggcauagcuggguagcuauguguggacgggauaagugcugaaagca
ucuaagcaugaagccccccucaagaugagauuucccaacuucgguuauaa
gaucccucaaagaugaugagguuaauagguucgagguggaagcaugguga
cauguggagcugacgaauacuaaucgaucgaagacuuaau

<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<......
<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>
>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>>.<<<
<<<<<<.........>>>>>>>.>>.>>....<<<<<......<......
>.......>>>>.>.........<<....>>..<<<<<......<<....
.>>.....>>>>>..(((....<<<<..>>>>......<<<<<<......
........<..<<<<<<.<<<...<<<<<......>>>>>((......<<
<.....))>>>...>>>...>>>>>>...>........>>..>>>>....
.<<<<<<<<.........>>>>>>>>......<<<<<..<<<<>>>>>..
)))......]].>>>>>>>.]]...............<<....>>....]
].........<<<<....>>>>..................>>>>>>>>>>
>.......<<<<..<<<<......>>>>..>>>>...<.<........>.
>.<<<<<<....<<<<<<<.<<<<<..<<<...<<<.....>>>...>>>
...<<....>>..<<<<.....>>>>.....>>>>>.>>>>>>>..<<.<
...<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>
.....>>>...<<<.<<<<<........>>>>>>>>....>>>>>>>>>.
..<<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<
<<....>>>>><<<<<<<<<...<<<<<<<<<.....<<<...<<<<<<<
<.>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<
<<<<<......>>>>>>>>>>....<<<......>>>...<<<<.<<<..
.<<<(((.....<<<<<<...........<<..<<<<.<.<<........
>>.>.>>>>.>>...........))).....>>>>>>.>>>...>>>>>>
><<<<<<.....>>>>>>....>>>>>><.<<<<<<<.<<......<<<<
<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>>>><......
<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<
...<<.....>>.>>>>>>....((<<<<.<<...<<<...<<<....>>
>...>>>...>>...<<<<<........>>>>>))<<<<<<<.......<
<...<<<<....<<<<...<<...<....<.<<<.........>>>.>.<
....<<<<...<<<........>>>...>>>>.....>.....<....>.
.......>....>>...>>>>.........>>>>..>>......>>>>>>
>>>>>..>>.....<<......>>>>>>>.<<<.......>>>..>>>>.
.<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..>>
.....>>>>><<<<<<<.<<<<....>>>>.>>>>>>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>
.......>>>>>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<
<..<<....>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<..
.....>>>>>>........<...........<<<<<<.....>>>>>>..
...>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.>..
...>.....<<<<<........>>>>>..<<<<<<<<.(((.[[......
<<<<.[[<<<<..<<<<<.<<<<<<<<<.<<<<.<..>.>>>>....<<.
<<<<<<.....>>>>>>>>.....>>>>>>>>>..>>>>>..<<<<....
.>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<
<.......>>>>>>.....<<.[.(((>>....>>>>>>>...<<<<..<
<<......>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.(
(..>>>>..))>>>>>>>.............>>>>..]]>>>>.......
<<<<.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.....
..<<<<<..<<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<..
...>>>>>.....>>>>>......>>>.>>....<<<<<<<....>>>.>
>>>....]]..)))>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.
..............>>>>>>>.<<<<<...<<<<...<<<<<<<<<<...
...>>>>>..>>>>>...>>>>.>>>>>...<<<.<..<<<<<.......
....>>>>>...>>>>.>>>>.......>>>>>>>.<<<....>>>....
<<<<<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....
>>>>>...>>>..>>>>>.>>>...>>>>....>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ttw A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): T13 K15 N34 K35 T36 K39 N54 M56 Y58 K59 K63 M65 Y68 G70 N73 R76
• Binding residue (residue number reindexed from 1): T10 K12 N31 K32 T33 K36 N51 M53 Y55 K56 K60 M62 Y65 G67 N70 R73

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7ttw, PDBe:7ttw, PDBj:7ttw
• PDBsum: 7ttw
• PubMed: 35736238
• UniProt: Q2FW08|RL23_STAA8 Large ribosomal subunit protein uL23 (Gene Name=rplW)