Structure of PDB 7tqq Chain F Binding Site BS01

Receptor Information
>7tqq Chain F (length=215) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTPTVPPPP
RVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAF
LRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKA
LERASKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWV
DAHARPFGTIRPMYG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tqq Structural basis of human TREX1 DNA degradation and autoimmune disease.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D18 E20 A21 G23 L24 F26 S78 A80 I84 T85 N125 R128 Y129 I156 S176 Y177 S178 L179
Binding residue
(residue number reindexed from 1)		D12 E14 A15 G17 L18 F20 S67 A69 I73 T74 N114 R117 Y118 I145 S157 Y158 S159 L160
Enzymatic activity
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7tqq, PDBe:7tqq, PDBj:7tqq
PDBsum7tqq
PubMed35879334
UniProtQ9NSU2|TREX1_HUMAN Three-prime repair exonuclease 1 (Gene Name=TREX1)

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