Structure of PDB 7ta6 Chain F Binding Site BS01

Receptor Information
>7ta6 Chain F (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRTPSDKPVAHVVANPQAEGQLQWLLLANGVELRDNQLVVPSEGLYLIYS
QVLFKGQGCPSTHVLLTHTISRIAYQTKVNLLSAIKSPCQRAKPWYEPIY
LGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
Ligand information
>7ta6 Chain L (length=29) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KLGWCIGEGGTDPNLNHGQFRGKILMCWK
Receptor-Ligand Complex Structure
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PDB7ta6 Trimer-to-Monomer Disruption Mechanism for a Potent, Protease-Resistant Antagonist of Tumor Necrosis Factor-alpha Signaling.
Resolution2.67 Å
Binding residue
(original residue number in PDB)		P8 S9 K11 V13 H15 L57 Y59 Q61 Y119 V123 Q149 Y151 I155 A156 L157
Binding residue
(residue number reindexed from 1)		P4 S5 K7 V9 H11 L47 Y49 Q51 Y100 V104 Q130 Y132 I136 A137 L138
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005164 tumor necrosis factor receptor binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7ta6, PDBe:7ta6, PDBj:7ta6
PDBsum7ta6
PubMed35613436
UniProtP01375|TNFA_HUMAN Tumor necrosis factor (Gene Name=TNF)

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