Structure of PDB 7t4s Chain F Binding Site BS01

Receptor Information
>7t4s Chain F (length=363) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEH
CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAK
DGFSARYYLVHQQCNVPLGMESGRIANEQISTPQQSRLHGDSNKEYLQVD
LRFLTMLTAIATQGYKLEVSTNGEDWMVYFQANNTEVVLNKLHAPLLTRF
VRIRPQLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAA
RLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGARARAFVRKF
KVSYSLNGKDWEYIQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSP
AGIGMRLEVLGCD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7t4s Chain F Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7t4s Structural basis for HCMV Pentamer receptor recognition and antibody neutralization.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E197 D211 T251 D252 V255
Binding residue
(residue number reindexed from 1)		E49 D54 T94 D95 V98
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005021 vascular endothelial growth factor receptor activity
GO:0017154 semaphorin receptor activity
Biological Process
GO:0001525 angiogenesis
GO:0007411 axon guidance
GO:0038084 vascular endothelial growth factor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7t4s, PDBe:7t4s, PDBj:7t4s
PDBsum7t4s
PubMed35275719
UniProtO60462|NRP2_HUMAN Neuropilin-2 (Gene Name=NRP2)

[Back to BioLiP]