Structure of PDB 7sr6 Chain F Binding Site BS01

Receptor Information
>7sr6 Chain F (length=566) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNS
PVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLIII
DLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTI
CQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVA
NAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKL
LGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEE
KIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKT
FTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAWQ
IGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRCEPLENALTVFTDGS
SNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYV
VQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLP
GPLTKANEQADLLVSS
Ligand information
Receptor-Ligand Complex Structure
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PDB7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		A334 N354
Binding residue
(residue number reindexed from 1)		A314 N334
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum7sr6
PubMed35771941
UniProtQ9UQG0|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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