Structure of PDB 7qh6 Chain F Binding Site BS01

Receptor Information
>7qh6 Chain F (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLD
ILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSP
LWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLE
LPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIP
AVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFP
Ligand information
>7qh6 Chain A (length=1133) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaagauu
uauagguagaggcgacaaaccuaccgagccuggugauagcugguugucca
agauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccu
uguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagga
aaaaaccuuguagagagaguaaaaaauuaucccaaacauauaacugaacu
ccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguua
guauaaguaacaugaaaacauucuccuccgcauaagccugcgucagacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaaaaucuuaccuguuuaccaaaaacaucaccucuagcaucaccag
uauuagaggcaccgcccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuaauaggguuuacgguucagaccgga
guaauccaggucgguuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>..>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..........>>
>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<
<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>....
.>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<.
.....>>>.>..<<<.<<<...<.....................>...>>
>>>>........>>>>>>...<<<<<......>>>>>.........>>>>
>><......<<..<<<....>>><<<<..<<<<........<<<<<.>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.............<<.........>>....<<<<<<..........
...>>>>>>..............>>.>>>>>>>>>>>>.>>.....>...
..<<<<<........>>>>>.......<<..<<<.........<<<<.<<
<<<<..<<<<..<<<<<<<<......>>>>>>>>.>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>.........<<<....>>>............>>>>
..>>>>>>........<<..<<<<<...>>>>..>.>>.....<<<<<<<
....>>>.>>>>.....>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>.......<<...........
.....>>..........<<<<.......>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7qh6 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
Resolution3.08 Å
Binding residue
(original residue number in PDB)
R92 I95 H97 M101 K104 N105 R108 Y111 K113 T114 K115 T116 R117 A118 V120 R121 G122 R125 K126 Q130 K131 G134 R135 A136 R137 H138 G139 I141 R142 P144 L145 W146 R147 G148 V151 H153 P155 Y161 Y163 M164 P166 M167 K168 V169 R170 K255 R281 P282 P285
Binding residue
(residue number reindexed from 1)
R48 I51 H53 M57 K60 N61 R64 Y67 K69 T70 K71 T72 R73 A74 V76 R77 G78 R81 K82 Q86 K87 G90 R91 A92 R93 H94 G95 I97 R98 P100 L101 W102 R103 G104 V107 H109 P111 Y117 Y119 M120 P122 M123 K124 V125 R126 K211 R237 P238 P241
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7qh6, PDBe:7qh6, PDBj:7qh6
PDBsum7qh6
PubMed35177605
UniProtQ9BYD3|RM04_HUMAN Large ribosomal subunit protein uL4m (Gene Name=MRPL4)

[Back to BioLiP]