Structure of PDB 7oic Chain F Binding Site BS01

Receptor Information
>7oic Chain F (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPVLRKVELPVPTHRRPVQAWVESLRGFEQERVGLADLHPDVFATAPRLD
ILHQVAMWQKNFKRISYAKTKTRAEVRGGGRKPWPQKGTGRARHGSIRSP
LWRGGGVAHGPRGPTSYYYMLPMKVRALGLKVALTVKLAQDDLHIMDSLE
LPTGDPQYLTELAHYRRWGDSVLLVDLTHEEMPQSIVEATSRLKTFNLIP
AVGLNVHSMLKHQTLVLTLPTVAFLEDKLLWQDSRYRPLYPFSLPYSDFP
Ligand information
>7oic Chain A (length=1383) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuaccaaaauaaaguauaggcgauagaaauugacuggcgcaauagaua
uaguaccgcaagggaaagaugaaaaaaccaagcauaauauagcaaggacu
aaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaagg
agagccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcu
aaaagagcacacccgucuauguagcaaaauagugggaagauuuauaggua
gaggcgacaaaccuaccgagccuggugauagcugguuguccaagauagaa
ucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauauaac
ugaacuccucacacccaauuggaccaaucuaucacccuauagaagaacua
auguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguc
agauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauu
auuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaa
aaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaac
aucaccucuagcaucaccaguauuagaggcaccgccuuggcuccacgagg
guucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaaga
ggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuuau
uaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucgga
gcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaagc
gaaccucaauugauccaauaacuugaccaacggaacaaguuacccuaggg
auaacagcgcaauccuauucuagaguccauaucaacaauaggguuuacga
ccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagguu
cguuuguucaacgauuaaaguccuacgugaucugaguucagaccggagua
auccaggucgguuucuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<...............................<....
..>...............<<.....>>..........>>.>>........
.....<<....>>.................>>>...........<<<...
....>>>...<.<........>.>.<<<<<<.........<<<.<<..<<
....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<
.....>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>>.
..<<.......>>......>.>>>>......>.>>..<<<<<<....<<<
<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>...........................
>...>>>>>>........>>>>>>...<<<<<......>>>>>.......
..>>>>>><......<<..<<<....>>><<<<..<<<<........<<<
<<...>>>>>......<<<...<<<<.......................>
>>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<..
.<<<<<<<<.<<.........<......<<<<<<..<<<.........>>
>...<<<<<<.............>>>>>>....<<<..>>>....>>.>>
>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<<......
..>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<.<
<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<<<
<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>>>
....>>.........<<<....>>>............>>>>..>>>>>>.
......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>>.
>.......<.<<<..<<<<<..<<.<<<<<<......>>>>>>...>>.<
<<<<.....>>>>>.....>>>>>......>>>..>....<<<<<<<...
.>>>.>>>>....>>..>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>......<<<...........
.....>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
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PDB7oic A distinct assembly pathway of the human 39S late pre-mitoribosome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
R92 I95 H97 M101 K104 N105 R108 S110 Y111 T114 K115 T116 R117 A118 V120 R121 R125 K126 Q130 K131 G132 T133 R135 A136 R137 H138 G139 R142 L145 W146 R147 G148 H153 P155 P158 Y161 Y163 M164 P166 M167 K168 V169 R170 K255 R281 P282 P285
Binding residue
(residue number reindexed from 1)
R48 I51 H53 M57 K60 N61 R64 S66 Y67 T70 K71 T72 R73 A74 V76 R77 R81 K82 Q86 K87 G88 T89 R91 A92 R93 H94 G95 R98 L101 W102 R103 G104 H109 P111 P114 Y117 Y119 M120 P122 M123 K124 V125 R126 K211 R237 P238 P241
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7oic, PDBe:7oic, PDBj:7oic
PDBsum7oic
PubMed34315873
UniProtQ9BYD3|RM04_HUMAN Large ribosomal subunit protein uL4m (Gene Name=MRPL4)

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