Structure of PDB 7mqs Chain F Binding Site BS01

Receptor Information
>7mqs Chain F (length=811) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKP
PSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRLEESSFRKTFE
DYLHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAA
YVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSY
RRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTE
PTYFYVTDYLD
Ligand information
>7mqs Chain A (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCHSLQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Resolution4.4 Å
Binding residue
(original residue number in PDB)		R488 N547 H548 P549 G550 W551 R554 K703 E706 D707 L709 H710
Binding residue
(residue number reindexed from 1)		R480 N530 H531 P532 G533 W534 R537 K647 E650 D651 L653 H654
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum7mqs
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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