Structure of PDB 7kif Chain F Binding Site BS01

Receptor Information
>7kif Chain F (length=322) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDESEALRQARKDAELTASADSVRAYLKQIGKVALLNAEEEVELAKRIEA
GLYATQLMTELSERGEKLPAAQRRDMMWICRDGDRAKNHLLEANLRLVVS
LAKRYTGRGMAFLDLIQEGNLGLIRAVEKFDYTKGYKFSTYATWWIRQAI
TRAMADQARTIRIPVHMVEVINKLGRIQRELLQDLGREPTPEELAKEMDI
TPEKVLEIQQYAREPISLDQTIGDEGDSQLGDFIEDSEAVVAVDAVSFTL
LQDQLQSVLDTLSEREAGVVRLRFGLTDGQPRTLDEIGQVYGVTRERIRQ
IESKTMSKLRHPSRSQVLRDYL
Ligand information
>7kif Chain O (length=63) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggtcagaaaatcggttgtggtcagctgctgccaccggttaacctccaatt
ctgctgccagcct
Receptor-Ligand Complex Structure
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PDB7kif Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.
Resolution2.94 Å
Binding residue
(original residue number in PDB)		L240 R301 L302 R330 D336 K339 Y341 K342 S344 T345 Y346 W349 W350 Q353 H371 R470 T499 R502
Binding residue
(residue number reindexed from 1)		L35 R96 L97 R125 D131 K134 Y136 K137 S139 T140 Y141 W144 W145 Q148 H166 R265 T294 R297
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009415 response to water
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kif, PDBe:7kif, PDBj:7kif
PDBsum7kif
PubMed34171296
UniProtP9WGI1|SIGA_MYCTU RNA polymerase sigma factor SigA (Gene Name=sigA)

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