Structure of PDB 7khb Chain F Binding Site BS01

Receptor Information
>7khb Chain F (length=471) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEA
ITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDTI
KATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLC
VEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRAL
QKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIA
KKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITR
SIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPE
DKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLR
AATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIE
AKALRKLRHPSRSEVLRSFLD
Ligand information
>7khb Chain X (length=60) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atttcctcttgtcaggccggaataactccctataatgcgccatgacacgg
actctacgag
Receptor-Ligand Complex Structure
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PDB7khb Structural basis of ribosomal RNA transcription regulation.
Resolution3.53 Å
Binding residue
(original residue number in PDB)		R99 M102 L110 R385 K392 E420 R423 Y425 K426 S428 T429 Y430 W433 W434 Q437 R451 P453 H455 R586 Q589
Binding residue
(residue number reindexed from 1)		R9 M12 L20 R244 K251 E279 R282 Y284 K285 S287 T288 Y289 W292 W293 Q296 R310 P312 H314 R445 Q448
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7khb, PDBe:7khb, PDBj:7khb
PDBsum7khb
PubMed33483500
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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