Structure of PDB 7chw Chain F Binding Site BS01

Receptor Information
>7chw Chain F (length=472) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDT
IKATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKL
CVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRA
LQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISI
AKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAIT
RSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMP
EDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESL
RAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQI
EAKALRKLRHPSRSEVLRSFLD
Ligand information
>7chw Chain H (length=63) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aacaaaatgattgacaaaagtgttaaattgtgctataatgggagctgtca
cggatgcagggga
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7chw Structural basis for transcription inhibition by E. coli SspA
Resolution3.58 Å
Binding residue
(original residue number in PDB)		M102 G106 R385 K392 E420 R423 Y425 K426 S428 T429 Y430 T432 W433 W434 Q437 P453 H455 R584 E585 K593
Binding residue
(residue number reindexed from 1)		M13 G17 R245 K252 E280 R283 Y285 K286 S288 T289 Y290 T292 W293 W294 Q297 P313 H315 R444 E445 K453
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7chw, PDBe:7chw, PDBj:7chw
PDBsum7chw
PubMed
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

[Back to BioLiP]