Structure of PDB 7c17 Chain F Binding Site BS01

Receptor Information
>7c17 Chain F (length=465) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAIT
YLLEQYDRVEAENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQE
EILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKM
PKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQI
EEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNR
GLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQA
RTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKV
LKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDV
LAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRK
LRHPSRSEVLRSFLD
Ligand information
>7c17 Chain 1 (length=58) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
attaatttcttgaccttccccttgctggaaggtttataatgggagctgtc
acggatgc
Receptor-Ligand Complex Structure
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PDB7c17 CueR activates transcription through a DNA distortion mechanism.
Resolution4.22 Å
Binding residue
(original residue number in PDB)		V98 R99 M102 G106 L111 R385 L386 I388 K392 F401 K418 F419 Y425 K426 T429 Y430 T432 W433 W434 Q437 R451 P453 H455 K493 K496 T583 E585 R586 K593
Binding residue
(residue number reindexed from 1)		V6 R7 M10 G14 L19 R238 L239 I241 K245 F254 K271 F272 Y278 K279 T282 Y283 T285 W286 W287 Q290 R304 P306 H308 K346 K349 T436 E438 R439 K446
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c17, PDBe:7c17, PDBj:7c17
PDBsum7c17
PubMed32989300
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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