Structure of PDB 7aud Chain F Binding Site BS01

Receptor Information
>7aud Chain F (length=516) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILM
PTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTG
DKTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLL
ARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQK
DILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYD
SGIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDG
CQVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHC
LLFYTYHDVTRLKRLIMMEKDGNHHTRETHFNNLYSMVHYCENITECRRI
QLLAYFGENGFNPDFCKKHPDVSCDNCCSKALVAKVSQREEMVKKCLGEL
TEVCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLE
KYGAEVISVLQKYSEW
Ligand information
Receptor-Ligand Complex Structure
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PDB7aud Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
Resolution2.96 Å
Binding residue
(original residue number in PDB)		L716 R717 T738 G739 T766 E768 K769 S773 N774 R775 F807 R808 L896 S897 R898 H919 A920 T946 K968 E1008
Binding residue
(residue number reindexed from 1)		L77 R78 T99 G100 T127 E129 K130 S134 N135 R136 F168 R169 L257 S258 R259 H280 A281 T307 K329 E369
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7aud, PDBe:7aud, PDBj:7aud
PDBsum7aud
PubMed33647232
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

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