Structure of PDB 7ask Chain F Binding Site BS01

Receptor Information

>7ask Chain F (length=1523) Species: 5693 (Trypanosoma cruzi)

MSSRYRELIAIFGEFLEENDFHVRISMDRVGEVKTLFSAKTIPVESETEA
AIEVVTIEAARRRDALRRTCNAVLRTRHSDQHVDVGTIVADEEERLAWKF
LIGALAAKNSEILPVVEAELLLAAVEYHYATARPELCDMFVHLSASEMFF
IDGDSLFMAALSPQSVDWDLIQPLHVIYNAQKLLYDMHCRGARFHVVFFD
SLLWIWESAPAKLFMRENLRKTLMSLSENDAKVGLSISNFSSYYSEAFET
YVKQWEPEFILMSDGEQLGRLNPLQAFFVRPSAANNTHDSRRKANYTDAD
EANPYRLRRQYRSIVEDEAVGDKSDDDAGGNSANNKTAGAKKVNKEHAGQ
RNKKERSKEDEIRERSNVIAATATVAEWHKQMNHLLHAVDMSHGRTTNRD
RDESINTIMAAIKRLSQEKFGKNFDPGYTLGGSTNTAVPLKLEMWRLLVA
ASQLREVEFAFAMEDPALKDSKGASKKKDSKSEYKMLYGFHVINQFVERE
AVKGNHWGQLDPLRKAKPDMTIVEARSYLRWVYLSFVEMHIQLKLKCRVV
KLQLENWRAERERARLAQESPKIALGIPLFLYCHHHVLAVIRDEGPRMSS
EDIDTVRSALKHFDLPDSYYNKLDQCIARWQNMTLGTLLPSLLPQDKQLF
ETPEMLQLIHMGHLLERPFVREHDYRVAFNPDNWQRELLDIVDGRGSAVV
CAPTSAGKTFISYYCMYKALRRTNKKVVVYLAPARALINQAVADVCARYG
SKKYKNPGRYIYGALGGADYHQFHDSCQVLLTVPETFETMLLSPKYTDWV
ELIDYVILDEIHSMESNGNGDVWERILALLPCPFVALSATLGETQQLCSW
LNRVQGRLKEQTEEMSGKMRDFEVHLLPSEGKSIQRWNDIKKYIYLPPPG
AALTQKKIKAQYNNCYIRDLHPLSILTADQLQRGFPPDISLVPSEVVSLF
EKMHSKFNEVVWPNYSSLQLAKTLRAQLMLIEPSKYFEAETYITQERARQ
YEAEVKNAFAYWAYLGHEGCELPENLVEEDLDDFSASMNMAVESILRTFA
QKLNEDEALLERHAADGMEKKKRMLLRQQHLQLLQQQEQENEPNQEESME
QKSEEQGGAQEEEQEKETVGSVSFPGSRQFIREHILNVLRELIARDMGPT
IVFSFESEDCGDLVKYVVEQLEEAESRYRKTNEFALYKARIERAAAAQEA
RRKQRESTLKQKRLTTGDDGDVEVADRDMSDGEGEDELFVVPDVLPEFTF
IGEKCTVEPEVVDSLMEDCEKEGEDLLLRALQRGIGMHHAGVKGKLRAHV
ERLFRGRHCGVIFSTETLALGIHSPCRSVVLAGDHILLNPTQFRQMMGRA
GRRGLDYLGHLVFLGITMRRIKRLMTSSMTVIKGNVQMDPISNLRLLQLY
DFNTLRHLKNEAGWKTHVLKLAERLFVNPLFFQGRNSVAGGNMEGFTVEW
LQMLLGYFQREGLHFSDHASSLGSILQDAMYVFREAHVGNEGFSFIRMLT
SGVFDKAHYSPLYDKKLNSGVLD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7ask Chain F Residue 2201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7ask Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts.
• Resolution: 4.3 Å
• Binding residue (original residue number in PDB): K1052 T1053
• Binding residue (residue number reindexed from 1): K708 T709
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7ask, PDBe:7ask, PDBj:7ask
• PDBsum: 7ask
• PubMed: 33357443
• UniProt: Q4E5Z1