Structure of PDB 6xsw Chain F Binding Site BS01
Receptor Information
>6xsw Chain F (length=229) Species:
9606
(Homo sapiens) [
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AACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNN
SRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCN
TEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAIL
RTSLRFRLDAHGQAMVFPYHRPEVIGSVVMLEIDNRLCLQSPDHCFPDAQ
SAADYLGALSAVERLDFPYPLRDVRGEPL
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
6xsw Chain F Residue 1701 [
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Receptor-Ligand Complex Structure
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PDB
6xsw
NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
Resolution
2.98 Å
Binding residue
(original residue number in PDB)
K1396 D1399 R1401 D1403 D1414 D1417
Binding residue
(residue number reindexed from 1)
K6 D9 R11 D13 D24 D27
Annotation score
4
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Biological Process
GO:0007219
Notch signaling pathway
GO:0007275
multicellular organism development
GO:0030154
cell differentiation
Cellular Component
GO:0016020
membrane
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Biological Process
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Cellular Component
External links
PDB
RCSB:6xsw
,
PDBe:6xsw
,
PDBj:6xsw
PDBsum
6xsw
PubMed
34095881
UniProt
Q9UM47
|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)
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