Structure of PDB 6xlj Chain F Binding Site BS01

Receptor Information
>6xlj Chain F (length=476) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYP
EAITYLLEQYDRVEAEEARLSDLITGFVDIDPELAREKFAELRAQYVVTR
DTIKHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLI
MKLCVEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEV
HRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLV
ISIAKKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQ
AITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERM
LMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATT
ESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERI
RQIEAKALRKLRHPSRSEVLRSFLDD
Ligand information
>6xlj Chain N (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccttgaccctcccctaaggggagggtttagattgtgtgcagtctgacgc
ggcg
Receptor-Ligand Complex Structure
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PDB6xlj Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		M102 G106 L110 N383 R385 L386 K392 F401 F419 E420 Y425 K426 S428 T429 Y430 W433 W434 Q437 R441 R451 P453 H455 R554 V582 T583 E585 R586 Q589
Binding residue
(residue number reindexed from 1)		M14 G18 L22 N246 R248 L249 K255 F264 F282 E283 Y288 K289 S291 T292 Y293 W296 W297 Q300 R304 R314 P316 H318 R417 V445 T446 E448 R449 Q452
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xlj, PDBe:6xlj, PDBj:6xlj
PDBsum6xlj
PubMed33976201
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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