Structure of PDB 6xl9 Chain F Binding Site BS01

Receptor Information
>6xl9 Chain F (length=465) Species: 83334 (Escherichia coli O157:H7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEAI
TYLLEQYDRVENSIDPELAREKFAELRAQYVVTRDTIKAKGRSHATAQEE
ILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMP
KKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIE
EETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRG
LQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQAR
TIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVL
KIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLRAATHDVL
AGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKALRKL
RHPSRSEVLRSFLDD
Ligand information
>6xl9 Chain N (length=54) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccttgaccctcccctaaggggagggtttagattgtgtgcagtctgacgc
ggcg
Receptor-Ligand Complex Structure
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PDB6xl9 Structural visualization of transcription activated by a multidrug-sensing MerR family regulator.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		M102 N383 R385 Y425 K426 S428 T429 Y430 W433 W434 Q437 H455 T583 R586
Binding residue
(residue number reindexed from 1)		M11 N235 R237 Y277 K278 S280 T281 Y282 W285 W286 Q289 H307 T435 R438
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xl9, PDBe:6xl9, PDBj:6xl9
PDBsum6xl9
PubMed33976201
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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