Structure of PDB 6wmu Chain F Binding Site BS01

Receptor Information
>6wmu Chain F (length=471) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPEA
ITYLLEQYDRVEAEEARLSDLITGFVDDPELAREKFAELRAQYVVTRDTI
KATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLC
VEQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRAL
QKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIA
KKYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITR
SIADQARTIRIPVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPE
DKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTESLR
AATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIE
AKALRKLRHPSRSEVLRSFLD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6wmu Structural Basis for Virulence Activation of Francisella tularensis.
Resolution3.18 Å
Binding residue
(original residue number in PDB)		M102 G106 L110 R385 L386 K392 R423 Y425 K426 S428 T429 T432 W433 W434 Q437 R451 P453 H455 R584 R586 Q589
Binding residue
(residue number reindexed from 1)		M12 G16 L20 R244 L245 K251 R282 Y284 K285 S287 T288 T291 W292 W293 Q296 R310 P312 H314 R443 R445 Q448
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6wmu, PDBe:6wmu, PDBj:6wmu
PDBsum6wmu
PubMed33217319
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

[Back to BioLiP]