Structure of PDB 6vvv Chain F Binding Site BS01
Receptor Information
>6vvv Chain F (length=302) Species:
246196
(Mycolicibacterium smegmatis MC2 155) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLP
VQQRRDMQWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEG
NLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVE
VINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLD
QTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGV
VRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR
DY
Ligand information
>6vvv Chain O (length=31) [
Search DNA sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
gcttgacaaaagtgttaaattgtgctatact
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
6vvv
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Resolution
3.2 Å
Binding residue
(original residue number in PDB)
N237 R239 L240 R268 K272 D274 K277 Y279 K280 S282 T283 Y284 T286 W287 W288 Q291 R295 R305 P307 H309 T437 E439 R440 Q443
Binding residue
(residue number reindexed from 1)
N75 R77 L78 R106 K110 D112 K115 Y117 K118 S120 T121 Y122 T124 W125 W126 Q129 R133 R143 P145 H147 T275 E277 R278 Q281
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003677
DNA binding
GO:0003700
DNA-binding transcription factor activity
GO:0016987
sigma factor activity
Biological Process
GO:0006352
DNA-templated transcription initiation
GO:0006355
regulation of DNA-templated transcription
GO:0010468
regulation of gene expression
GO:2000142
regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:6vvv
,
PDBe:6vvv
,
PDBj:6vvv
PDBsum
6vvv
PubMed
33199626
UniProt
A0QW02
[
Back to BioLiP
]