Structure of PDB 6vvv Chain F Binding Site BS01

Receptor Information
>6vvv Chain F (length=302) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADSVRAYLKQIGKVALLNAEEEVELAKRIEAGLYATQKLAELAEKGEKLP
VQQRRDMQWICRDGDRAKNHLLEANLRLVVSLAKRYTGRGMAFLDLIQEG
NLGLIRAVEKFDYTKGYKFSTYATWWIRQAITRAMADQARTIRIPVHMVE
VINKLGRIQRELLQDLGREPTPEELAKEMDITPEKVLEIQQYAREPISLD
QTIGDEGDSQLGDFIEDSEAVVAVDAVSFTLLQDQLQSVLETLSEREAGV
VRLRFGLTDGQPRTLDEIGQVYGVTRERIRQIESKTMSKLRHPSRSQVLR
DY
Ligand information
Receptor-Ligand Complex Structure
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PDB6vvv The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
Resolution3.2 Å
Binding residue
(original residue number in PDB)
N237 R239 L240 R268 K272 D274 K277 Y279 K280 S282 T283 Y284 T286 W287 W288 Q291 R295 R305 P307 H309 T437 E439 R440 Q443
Binding residue
(residue number reindexed from 1)
N75 R77 L78 R106 K110 D112 K115 Y117 K118 S120 T121 Y122 T124 W125 W126 Q129 R133 R143 P145 H147 T275 E277 R278 Q281
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0016987 sigma factor activity
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0010468 regulation of gene expression
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6vvv, PDBe:6vvv, PDBj:6vvv
PDBsum6vvv
PubMed33199626
UniProtA0QW02

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