Structure of PDB 6spf Chain F Binding Site BS01

Receptor Information
>6spf Chain F (length=174) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RLKELYRKEIAPKLKEELQLANVMEVPRVTKITLNMGLGEAVGDKKIIEN
AVADLEKITGQKPVVTYARKSIAGFKIREGWPIGVKVTLRSDRMYEFLDR
LLSISLPRVRDFRGLNAKSFDGRGNYSMGVKEQIIFPEIDYDKIDALRGL
DITLTTTARTDDEGRALLRAFKFP
Ligand information
>6spf Chain A (length=2885) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucaagugaagaagcgcauacgguggaugccuuggcagucagaggcgaug
aaagacgugguagccugcgaaaagcuucggggagucggcaaacagacuuu
gauccggagaucucugaaugggggaacccaccuaggauaaccuagguauc
uuguacugaauccauaggugcaagaggcgaaccaggggaacugaaacauc
uaaguacccugaggaaaagaaaucaaccgagauucccuuaguaguggcga
gcgaacggggauuagcccuuaagcuucauugauuuuagcggaacgcucug
gaaagugcggccauagugggugauagccccguacgcgaaaggaucuuuga
agugaaaucaaguaggacggagcacgagaaacuuugucugaacauggggg
gaccauccuccaaggcuaaauacuacugacugaccgauagugaaccagua
ccgugagggaaaggcgaaaagaaccccggagaggggagugaaauagaacc
ugaaaccguaugcguacaagcagugggagccuacuuguuaggugacugcg
uaccuuuuguauaaugggucagcgacuuauauucaguggcaagcuuaacc
guauaggguaggcguagcgaaagcgagucuuaauagggcguuuagucgcu
ggguauagacccgaaaccgggcgaucuauccaugagcagguugaagguua
gguaacacugacuggaggaccgaacccacucccguugaaaagguagggga
ugacuuguggaucggagugaaaggcuaaucaagcucggagauagcugguu
cuccucgaaagcuauuuagguagcgccucauguaucacucugggggguag
agcacuguuucggcuagggggucaucccgacuuaccaaaccgaugcaaac
uccgaauacccagaagugccgagcaugggagacacacggcgggugcuaac
guccgucgugaaaagggaaacaacccagaccgccagcuaaggucccaaag
uugugguuaagugguaaacgaugugggaaggcuuagacagcuaggagguu
ggcuuagaagcagccacccuuuaaagaaagcguaauagcucacuagucga
gucggccugcgcggaagauguaacggggcucaaaccacacaccgaagcug
cgggugucacguaagugacgcgguagaggagcguucuguaagccugugaa
ggugaguugagaagcuugcuggagguaucagaagugcgaaugcugacaug
aguaacgacaaugggugugaaaaacacccacgccgaaagaccaaggguuc
cugcgcaacguuaaucgacgcaggguuagucgguuccuaaggcgaggcug
aaaagcguagucgaugggaaacagguuaauauuccuguacuucugguuac
ugcgauggagggacggagaaggcuaggccagcuuggcguugguuguccaa
guuuaaggugguaggcugaaaucuuagguaaauccgggguuucaaggccg
agagcugaugacgagucgucuagaugacgaagugguugaugccaugcuuc
caagaaaagcuucuaagcuucagguaaccaggaaccguaccccaaaccga
cacagguggucggguagagaauaccaaggcgcuugagagaacucggguga
aggaacuaggcaaaauggcaccguaacuucgggagaaggugcgccggcua
gggugaaggauuuacuccguaagcucuggcuggucgaagauaccaggccg
cugcgacuguuuauuaaaaacacagcacucugcaaacacgaaaguggacg
uauagggugugacgccugcccggugccggaagguuaauugaugggguuag
cgcaagcgaagcucuugaucgaagccccgguaaacggcggccguaacuau
aacgguccuaagguagcgaaauuccuugucggguaaguuccgaccugcac
gaauggcguaacgauggcggcgcugucuccacccgagacucagugaaauu
gaaaucgcugugaagaugcaguguauccgcggcuagacggaaagaccccg
ugaaccuuuacuguagcuuugcacuggacuuugagccugcuuguguagga
uaggugggaggcuuugaagcguggacgccaguucgcguggagccauccuu
gaaauaccacccuggcaugcuugagguucuaacucugguccguaauccgg
aucgaggacaguguauggugggcaguuugacuggggcggucuccuccuaa
agaguaacggaggaguacgaaggugcgcucagaccggucggaaaucgguc
gcagaguauaaaggcaaaagcgcgcuugacugcgagacagacacgucgag
cagguacgaaaguaggucuuagugauccggugguucuguauggaagggcc
aucgcucaacggauaaaagguacuccggggauaacaggcugauaccgccc
aagaguucauaucgacggcgguguuuggcaccucgaugucggcucaucac
auccuggggcugaagccggucccaaggguauggcuguucgccauuuaaag
ugguacgcgagcuggguuuagaacgucgugagacaguucggucccuaucu
gccguggacguuugagauuugagaggggcugcuccuaguacgagaggacc
ggaguggacgaaccucugguguuccgguugucacgccaguggcauugccg
gguagcuauguucggaaaagauaaccgcugaaagcaucuaagcgggaaac
uugccucaagaugagaucucacugggaacuugauuccccugaagggccgu
cgaagacuacgacguugauaggcuggguguguaagcguugugaggcguug
agcuaaccaguacuaauggcccgugaggcuugacc
<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<....
..<<<<<<.[..(((.>>>.....<<<<<<<..<<<)))...].>>>...
..>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<<
<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>>
......>>>>>.>.........<<....>>...<<<<<.....<<.....
>>....>>>>>...(((.....<<<<<<..<<<<<..<<<...<<<....
......>>>((......<<<.....))>>>...>>>....>>>>>..>>>
>>>...........<<<<<<<<.........>>>>>>>>......<<<<<
..<<<<>>>>>..)))......]].>>>>>>>.]]...............
<<....>>....]].........<<<<.....>>>>..............
....>>>>>>>>>>>.......<<<<..<<<<<.....>>>>>..>>>>.
..<.<........>.>.<<<<<<....<<<<<<<<<<<<<..<<<...<<
.....>>...>>>...<<....>>..<<.<.....>.>>.....>>>>>>
>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<
<......>>>>>>.....>>>...<<<.<<.<<........>>.>>>>>.
...>>>>>>>>>...<<<.....>>>......>>>>>>...>..>.>>..
<<<<<<....<<<<<....>>>>>.<<<<<<<<..<<<<<<<<<.....<
<<...<<<.<<<<...<<................>>...>>>>.>>>..>
>.>.....>>>>>>.>>>....>>>>>>>.>...<<<<<<<<<<......
>>>>>>>>>>....<<<......>>>...<<<<.<<<...<<<(((....
.<<<<<<...........<<..<<<<<..<<...................
..................................................
.>>..>>>>>.>>...........)))......>>>>>>.>>>...>>>>
>>><<<<<<......>>>>>>....>>>>>>..<<<<<...<<<......
<<<<<<<<....>>>>>>>>...>>>..>>>>>........>>>>>><..
....<<.....<<<<<<.......>>>>>><<<<....<<<<<.<<...<
<<<<<...<<.....>>.>>>>>>....((<<<<<<<...<<<...<<<.
...>>>...>>>...>>>..<<<<<........>>>>>))<<<<<<<<<<
.<<...<<<<....<<<<..<<<..<<<<<..<<<<...((((...>>>>
..<<...<<....<<<<<<<<<<<..<<.....>>.>>>>>>>..>>>>.
...>>....>><..<<<.<<..>>.>>>...>>>>>>...>>>...>>>>
.........>>>>...>>.....>>>>>>>>>>>>>>..>>.....<<..
....>>>>>>>.<<<<.....>>>>..>>>>..<<<<....<<<<<<<<.
<<...............<<<<<....<<..>>.....>>>>><<<<<<<<
<<<<...<<<.....>>>....>>>>>>>>>>>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<.....<<<....>>>....
...>>>>>>>.<<<<<.<<<..<<<<<<<..<<<<.......<<<<<<.<
<....>>..>>>>>>.......>>>>>>>>>..>>>>><<..........
.....>>........<...........<<<<<<.....>>>>>>.....>
....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>>>>.....>
.....<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<
.[[<<<<..<<<<<.<<<.<<<<<.<<.<<<<<<<<.<.<..........
..<<<<................<<<<....>>>>................
.......>>>>...>.>.>>>>>>>>.>>...<<<.<<<<<<.....>>>
>>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<...
........>>>>>>..<<.....<<<<<...<<<<<.........>>>>>
.....<<.[.(((>>....>>>>>.....<<<<..<<<......>>>..>
>>>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>
>>>>.............>>>>..]]>>>>.......<<<<.<.<<<<<<.
..<<.......>>...>>>>>>...>>>>.>.......<<<<<.<<<<<<
..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))
>>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............
>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))))>>>>>>..>>>>
>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>
>>.>>>>.......>>>>>>>..<<<<<.....>>>>>.....<<..<<<
<<.......>>>>>....<<<.<<<<.<<<.....<<<......>>>...
.>>.>.>>>>..>>>.....>>.....>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6spf Structure ofPseudomonas aeruginosaribosomes from an aminoglycoside-resistant clinical isolate.
Resolution2.89 Å
Binding residue
(original residue number in PDB)
N37 G39 G41 F77 K78 I85 K88 K133
Binding residue
(residue number reindexed from 1)
N35 G37 G39 F75 K76 I83 K86 K131
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6spf, PDBe:6spf, PDBj:6spf
PDBsum6spf
PubMed31611393
UniProtA0A072ZMU2

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