Structure of PDB 6qxe Chain F Binding Site BS01

Receptor Information
>6qxe Chain F (length=611) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMRVNKRSYLIRALTLNTMTKDA
ERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAK
LANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPE
WFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYF
NESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRY
TKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKK
SYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIK
NNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWE
QTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPF
VTTHSWIPKRN
Ligand information
Receptor-Ligand Complex Structure
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PDB6qxe Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Resolution4.15 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 Y38 K237 R238 M356 K363 R365
Binding residue
(residue number reindexed from 1)		H32 G33 T34 Y38 K206 R207 M325 K332 R334
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qxe, PDBe:6qxe, PDBj:6qxe
PDBsum6qxe
PubMed31485076
UniProtP03432|RDRP_I68A6 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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