Structure of PDB 6peq Chain F Binding Site BS01

Receptor Information
>6peq Chain F (length=134) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFTFAAFCYMLSLVLCAALIFFAIWHIIAFDELRTDFVHARERLRNIERI
CFLLRKLVLPEYSIHSLFCIMFLCAQEWLTLGLNVPLLFYHFWRYFHCNA
DTLSYCQKEAWCKLAFYLLSFFYYLYCMIYTLVS
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain6peq Chain F Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6peq Structures of the AMPA receptor in complex with its auxiliary subunit cornichon.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		A18 L157
Binding residue
(residue number reindexed from 1)		A17 L132
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0016247 channel regulator activity
Biological Process
GO:0016192 vesicle-mediated transport
GO:0035249 synaptic transmission, glutamatergic
GO:0042391 regulation of membrane potential
GO:0051668 localization within membrane
GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane
GO:2000311 regulation of AMPA receptor activity
Cellular Component
GO:0005886 plasma membrane
GO:0032281 AMPA glutamate receptor complex
GO:0043198 dendritic shaft
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0098978 glutamatergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6peq, PDBe:6peq, PDBj:6peq
PDBsum6peq
PubMed31806817
UniProtQ6ZWS4|CNIH3_MOUSE Protein cornichon homolog 3 (Gene Name=Cnih3)

[Back to BioLiP]