Structure of PDB 6p18 Chain F Binding Site BS01

Receptor Information
>6p18 Chain F (length=325) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCSVAEYPE
AITYLLEQYDRVEAEEARLSDLITGFELAREKFAELRAQYVVTRDTIKAH
ATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCV
EQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQ
KLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAK
KYTNRGLQFLDLIQEGNIGLMKAVDKFEYRRGYKFSTYATWWIRQAITRS
IADQARTIRIPVHMIETINKLNRIS
Ligand information
>6p18 Chain 1 (length=56) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tcattgagcaaatgagcaacactattcgcatataatggggttagtgactc
ttaagt
Receptor-Ligand Complex Structure
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PDB6p18 Structural basis of Q-dependent antitermination.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		V98 R99 M102 M105 L110 N383 R385 L386 S389 E420 R423 Y425 K426 S428 T429 Y430 W433 W434 Q437 R451 H455
Binding residue
(residue number reindexed from 1)		V9 R10 M13 M16 L21 N241 R243 L244 S247 E278 R281 Y283 K284 S286 T287 Y288 W291 W292 Q295 R309 H313
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
GO:0016987 sigma factor activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0006352 DNA-templated transcription initiation
GO:0006355 regulation of DNA-templated transcription
GO:0009408 response to heat
GO:0010468 regulation of gene expression
GO:0045892 negative regulation of DNA-templated transcription
GO:2000142 regulation of DNA-templated transcription initiation
Cellular Component
GO:0000345 cytosolic DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1903865 sigma factor antagonist complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6p18, PDBe:6p18, PDBj:6p18
PDBsum6p18
PubMed31455742
UniProtP00579|RPOD_ECOLI RNA polymerase sigma factor RpoD (Gene Name=rpoD)

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