Structure of PDB 6p07 Chain F Binding Site BS01

Receptor Information
>6p07 Chain F (length=300) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSVKGVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMVILPSVR
PELFTGLRAPAKGLLLFGPPGNGKTLLARAVATECSATFLNISAASLTSK
YVGDGEKLVRALFAVARHMQPSIIFIDQVDSLLSERSSSEHEASRRLKTE
FLVEFDGLPGNPDGDRIVVLAATNRPQELDEAALRRFTKRVYVSLPDEQT
RELLLNRLLQKQGSPLDTEALRRLAKITDGYSGSDLTALAKDAALEPIRE
LNVEQVKCLDISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGD
Ligand information
>6p07 Chain G (length=15) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EEEEEEEEEEEEEEE
Receptor-Ligand Complex Structure
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PDB6p07 An allosteric network in spastin couples multiple activities required for microtubule severing.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		K555 Y556 V557 H596 A598
Binding residue
(residue number reindexed from 1)		K100 Y101 V102 H141 A143
Enzymatic activity
Enzyme Commision number 5.6.1.1: microtubule-severing ATPase.
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008568 microtubule severing ATPase activity
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:6p07, PDBe:6p07, PDBj:6p07
PDBsum6p07
PubMed31285604
UniProtA0A0B4LHJ5

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